A new antibacterial strategy is reported based on two-photon fabrication of three-dimensional curcumin-embedded μ-cages. Such devices were designed to entrap and kill Staphylococcus aureus bacteria upon visible light irradiation. The proposed concept mainly relies on the pivotal role of curcumin, which is sequentially used as a two-photon active free radical initiator and as a photogenerator of reactive oxygen species within the cage μ-volumes. We show that these μ-cages exhibit extremely high antimicrobial properties, leading to 95% bacteria mortality after only 10 min visible irradiation. A preconcentration mechanism of photogenerated oxygen species is proposed to account for this highly performing bactericidal effect whose virulence can be strikingly switched on by increasing the light exposure time from 5 to 10 min.

中文翻译：

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通过双光子聚合制备的姜黄素基μ-笼具有强力杀菌作用。

据报道，一种新的抗菌策略是基于二维姜黄素包埋的μ-笼的两光子制造。设计此类装置以在可见光照射下捕获并杀死金黄色葡萄球菌细菌。所提出的概念主要依赖于姜黄素的关键作用，姜黄素被依次用作双光子活性自由基引发剂和笼型微体积内活性氧的光发生剂。我们显示，这些μ笼展示了极高的抗菌性能，仅在10分钟可见光照射后导致95％的细菌死亡。提出了一种光生氧物种的预浓缩机制，以解决这种高性能的杀菌作用，通过将曝光时间从5分钟增加到10分钟，可以显着地开启其毒力。