Abstract This paper describes the preparation and characterization of a versatile Losartan-controlled-release material based on a functionalized cellulosic matrix grafted with the ionic liquid, [(MeO)3Sipmim][Cl]: 1–(trimethoxysilylpropyl)–3–methylimidazolium Chloride. A silanized ionic liquid was used as a solvent and a surface modification agent at the same time, allowing higher anionic drug loading capacity. The anionic Losartan drug release kinetics were evaluated as a model. The Losartan release was made using two distinct media, one at pH 7.4 and the other at 3.0 to simulate blood and stomach pH, respectively. Higher Losartan release-rate 88% at blood pH after 1085 min in comparison with 84% at stomach pH, after 330 min was attained. The higher Losartan release profile in acid pH compared with neutral pH could be associated to the hydrolysis of Si-O bond from the ionic liquid, with the acidic medium acting as a catalyst. This cellulosic matrix modified with ionic liquid showed promising for applications over a wide range of pH-controlled-release systems.

中文翻译：

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多功能接枝微晶纤维素与离子液体作为新型氯沙坦控释材料

摘要 本文描述了一种多功能氯沙坦控释材料的制备和表征，该材料基于接枝有离子液体 [(MeO)3Sipmim][Cl]: 1-(三甲氧基甲硅烷基丙基)-3-甲基咪唑鎓氯化物的官能化纤维素基质。硅烷化离子液体同时用作溶剂和表面改性剂，允许更高的阴离子载药量。阴离子氯沙坦药物释放动力学作为模型进行评估。氯沙坦的释放是使用两种不同的介质进行的，一种是 pH 7.4，另一种是 3.0，分别模拟血液和胃的 pH 值。1085 分钟后血液 pH 值下氯沙坦的释放率更高，为 88%，而胃 pH 值下为 84%，330 分钟后达到。与中性 pH 值相比，酸性 pH 值下氯沙坦的释放曲线更高，这可能与离子液体中 Si-O 键的水解有关，酸性介质充当催化剂。这种用离子液体改性的纤维素基质显示出在广泛的 pH 控制释放系统中的应用前景。