Emerging evidence from a systematic review of safety of pre‐exposure prophylaxis for pregnant and postpartum women: where are we now and where are we heading?,Journal of the International AIDS Society

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Emerging evidence from a systematic review of safety of pre‐exposure prophylaxis for pregnant and postpartum women: where are we now and where are we heading?
Journal of the International AIDS Society ( IF 4.6 ) Pub Date : 2020-01-01 , DOI: 10.1002/jia2.25426
Dvora L Joseph Davey _{1,

2} , Jillian Pintye ₃ , Jared M Baeten _{3,

4,

5} , Grace Aldrovandi ₆ , Rachel Baggaley ₇ , Linda-Gail Bekker ₈ , Connie Celum ₃ , Benjamin H Chi ₉ , Thomas J Coates ₆ , Jessica E Haberer ₁₀ , Renee Heffron _{3,

4} , John Kinuthia _{3,

11} , Lynn T Matthews ₁₂ , James McIntyre _{2,

13} , Dhayendre Moodley _{14,

15} , Lynne M Mofenson ₁₆ , Nelly Mugo _{3,

17} , Landon Myer ₂ , Andrew Mujugira _{3,

18} , Steven Shoptaw _{6,

19} , Lynda Stranix-Chibanda ₂₀ , Grace John-Stewart _{3,

4} ,

Affiliation

Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Department of Global Health, University of Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.
Department of Medicine, University of Washington, Seattle, WA, USA.
Geffen School of Medicine, University of California, Los Angeles, CA, USA.
World Health Organization, Geneva, Switzerland.
Faculty of Health Sciences, Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, NC, South Africa.
Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Center for Global Health, Massachusetts General Hospital, Boston, MA, USA.
Department of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Department of Medicine, University of Alabama, Birmingham, AL, USA.
ANOVA, Johannesburg, South Africa.
Department of Obstetrics and Gynaecology, University of KwaZulu-Natal, Durban, South Africa.
Centre for AIDS Research in South Africa, Durban, South Africa.
Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA.
Center for Clinical Research, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Department of Family Medicine, University of California, Los Angeles, CA, USA.
University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.

HIV incidence is high during pregnancy and breastfeeding with HIV acquisition risk more than doubling during pregnancy and the postpartum period compared to when women are not pregnant. The World Health Organization recommends offering pre‐exposure prophylaxis (PrEP) to pregnant and postpartum women at substantial risk of HIV infection. However, maternal PrEP national guidelines differ and most countries with high maternal HIV incidence are not offering PrEP. We conducted a systematic review of recent research on PrEP safety in pregnancy to inform national policy and rollout.

中文翻译：

对孕妇和产后妇女暴露前预防的安全性进行系统评价的新证据：我们现在在哪里以及我们将走向何方？

怀孕和母乳喂养期间艾滋病毒感染率很高，与未怀孕时相比，怀孕期间和产后感染艾滋病毒的风险增加一倍多。世界卫生组织建议为感染 HIV 的孕妇和产后妇女提供暴露前预防 (PrEP)。然而，孕产妇 PrEP 国家指南有所不同，大多数孕产妇 HIV 发病率较高的国家不提供 PrEP。我们对妊娠期 PrEP 安全性的最新研究进行了系统回顾，为国家政策和推广提供信息。

更新日期：2020-01-01

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