In this issue of Cell Host & Microbe, Hancock et al., 2020 show that latent HCMV infection, and specifically miR-US5-2, induces TGF-β secretion, which inhibits myelopoiesis in uninfected HPCs. They also show that HCMV-infected cells become resistant to TGF-β signaling through targeting of SMAD3 by miR-UL22-A-3p and -5p.

中文翻译：

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人类巨细胞病毒潜伏期和骨髓抑制：依赖于 microRNA 的阴阳调节环。

在本期 Cell Host & Microbe 中，Hancock 等人，2020 年表明，潜在的 HCMV 感染，特别是 miR-US5-2，会诱导 TGF-β 分泌，从而抑制未感染 HPC 的骨髓生成。他们还表明，通过 miR-UL22-A-3p 和 -5p 靶向 SMAD3，HCMV 感染的细胞对 TGF-β 信号传导产生抗性。