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A Reactive Oxygen Species (ROS) Activated Hydrogen Sulfide (H2S) Donor with Self-Reporting Fluorescence.
ACS Sensors ( IF 8.2 ) Pub Date : 2020-02-20 , DOI: 10.1021/acssensors.9b01093 Ning Zhang 1 , Ping Hu 1 , Yanfang Wang 2 , Qing Tang 1 , Qiang Zheng 1 , Zhanlong Wang 1 , Yun He 1
ACS Sensors ( IF 8.2 ) Pub Date : 2020-02-20 , DOI: 10.1021/acssensors.9b01093 Ning Zhang 1 , Ping Hu 1 , Yanfang Wang 2 , Qing Tang 1 , Qiang Zheng 1 , Zhanlong Wang 1 , Yun He 1
Affiliation
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Hydrogen sulfide (H2S) is an important cellular signaling molecule, and its physiological and pathophysiological properties have been under intensive investigation. In this study, a novel ratiometric fluorescent H2S donor (HSD-B) has been developed, which exhibited the following advantages: (i) scavenging ROS and producing H2S simultaneously; (ii) providing ratiometric fluorescence for visualization and quantification of H2S releasing; and (iii) targeting mitochondrion specifically. Moreover, it demonstrated protective effects on myocardial ischemia reperfusion injury in a cellular model. These attractive features promise this HSD-B as a fluorescent H2S donor for future research studies.
中文翻译：
具有自报告荧光的活性氧（ROS）活化的硫化氢（H2S）供体。
硫化氢（H2S）是重要的细胞信号分子，其生理和病理生理特性已得到深入研究。在这项研究中，开发了一种新型的比例荧光H2S供体（HSD-B），它具有以下优点：（i）清除ROS同时生产H2S；（ii）提供比例荧光，以可视化和量化H2S的释放；（iii）专门针对线粒体。此外，它在细胞模型中显示出对心肌缺血再灌注损伤的保护作用。这些诱人的功能使该HSD-B成为未来研究的荧光H2S供体。
更新日期：2020-02-20
中文翻译：
具有自报告荧光的活性氧（ROS）活化的硫化氢（H2S）供体。
硫化氢（H2S）是重要的细胞信号分子，其生理和病理生理特性已得到深入研究。在这项研究中，开发了一种新型的比例荧光H2S供体（HSD-B），它具有以下优点：（i）清除ROS同时生产H2S；（ii）提供比例荧光，以可视化和量化H2S的释放；（iii）专门针对线粒体。此外，它在细胞模型中显示出对心肌缺血再灌注损伤的保护作用。这些诱人的功能使该HSD-B成为未来研究的荧光H2S供体。
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