BACKGROUND Psoriasis is a multifactorial disorder, impacted by both genetic and environmental factors. Herein, a meta-analysis assessed the association of angiotensin-converting enzyme gene insertion/deletion (ACE I/D) polymorphism and psoriasis susceptibility. METHODS A systematic search was used in databases of PubMed/Medline, Scopus, Web of Science, and Cochrane Library up to January 2019 without language restriction. A dichotomous analysis was carried out by RevMan 5.3 using crude odds ratio (OR) and 95% confidence interval (CI) to investigate the association between ACE I/D polymorphisms and the risk of psoriasis. A funnel plot analysis was used by CMA 2.0 to estimate a significant existence of publication bias. RESULTS Out of 61 studies retrieved from the databases, 16 studies were included in the meta-analysis. The pooled ORs for models of D vs. I, DD vs. II, ID vs. II, ID + DD vs. II, and DD vs. II + ID genotypes were 0.96 [95%CI: 0.82, 1.12; P = 0.58], 0.99 [95%CI, 0.73, 1.36; P = 0.96], 0.81 [95%CI, 0.72, 0.91; p: 0.0003], 0.91 [95%CI, 0.73, 1.13; P = 0.40], and 1.05 [95%CI, 0.85, 1.30; P = 0.68], respectively. A significant difference between ACE polymorphisms in patients with/without family history for the disease [OR = 1.44; 95%CI: 1.24, 1.67; P < 0.001] and also in patients mild/severe psoriasis [OR = 0.70; 95%CI: 0.55, 0.88; P = 0.002] was identified. CONCLUSION The results of the meta-analysis showed that ACE I/D polymorphism may be associated with psoriasis susceptibility, while ID genotype seemed to have a protective role in Caucasian patients affected by psoriatic arthritis and in studies with hospital-based controls.

中文翻译：

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血管紧张素转换酶基因插入/缺失多态性与银屑病易感性：系统评价和荟萃分析。


背景银屑病是一种多因素疾病，受遗传和环境因素的影响。在此，一项荟萃分析评估了血管紧张素转换酶基因插入/缺失 (ACE I/D) 多态性与银屑病易感性的关联。方法 对截至 2019 年 1 月的 PubMed/Medline、Scopus、Web of Science 和 Cochrane Library 数据库进行系统检索，无语言限制。 RevMan 5.3 使用粗比值比 (OR) 和 95% 置信区间 (CI) 进行二分分析，以研究 ACE I/D 多态性与银屑病风险之间的关联。 CMA 2.0 使用漏斗图分析来估计发表偏倚的显着存在。结果 从数据库中检索到 61 项研究，其中 16 项研究纳入荟萃分析。 D 与 I、DD 与 II、ID 与 II、ID + DD 与 II 以及 DD 与 II + ID 基因型模型的合并 OR 为 0.96 [95% CI: 0.82, 1.12; P = 0.58], 0.99 [95%CI, 0.73, 1.36; P = 0.96], 0.81 [95%CI, 0.72, 0.91; p: 0.0003], 0.91 [95% CI, 0.73, 1.13; P = 0.40] 和 1.05 [95% CI，0.85，1.30； P = 0.68]，分别。有/无该疾病家族史的患者 ACE 多态性之间存在显着差异 [OR = 1.44； 95%置信区间: 1.24, 1.67; P < 0.001] 以及轻度/重度银屑病患者 [OR = 0.70； 95%置信区间：0.55、0.88； P = 0.002] 被确定。结论 荟萃分析的结果表明，ACE I/D 多态性可能与银屑病易感性相关，而 ID 基因型似乎在受银屑病关节炎影响的白种人患者以及医院对照研究中具有保护作用。