BACKGROUND Preclinical studies indicate iron deficiency (ID) plays an important role in cardiac remodelling. However, the relationship between ID and cardiac remodelling remains unknown in clinical setting. This retrospective study aims to identify a potential biomarker for the myocardial remodelling in patients with ID. Due to limited patients with ID are identified without iron deficiency anaemia (IDA), we analyse the relationship of total iron binding capacity (TIBC) and the left ventricular mass index (LVMI) in patients with iron deficiency anaemia. METHODS A total of 82 patients with IDA exhibiting the diagnostic criteria for IDA were enrolled in the study. Among the patients, 65 had reported LVMI values. Subsequently, these patients were divided into two groups according to abnormal LVMI (> 115 g/m2 in men and > 95 g/m2 in women). Linear bivariate analysis was performed to detect the associations of haemoglobin or TIBC with clinical and echocardiographic characteristics. Simple linear regression analysis was used to evaluate the correlation between LVMI and the parameters of IDA, while multivariable linear analysis was used to assess the association of LVMI with age, TIBC and haemoglobin. Logistic regression analysis was utilized to determine the relationship of LV remodelling with anaemia severity and TIBC. RESULTS As compared with control group, the levels of TIBC in abnormal LVMI group are increased. Using log transformed LVMI as the dependent variable, simultaneously introducing age, TIBC, and haemoglobin into the simple linear regression or multivariable linear regression analysis confirmed the positive association among these factors. Bivariate correlation analysis reveals the irrelevance between haemoglobin and TIBC. In logistic regression analysis, TIBC is associated with the risk of LV remodelling. CONCLUSIONS Results of study indicate that TIBC exhibit an explicit association with LVMI in patients with iron deficiency anaemia. Logistic analysis further confirms the contribution of TIBC to abnormal LVMI incidence among this population with IDA.

中文翻译：

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总铁结合能力（TIBC）是铁缺乏性贫血患者左心室重构的潜在生物标志物。

背景技术临床前研究表明，铁缺乏症（ID）在心脏重塑中起重要作用。但是，ID和心脏重塑之间的关系在临床环境中仍然未知。这项回顾性研究旨在确定ID患者心肌重塑的潜在生物标志物。由于确定的ID患者有限，没有缺铁性贫血（IDA），因此我们分析了缺铁性贫血患者的总铁结合能力（TIBC）与左心室质量指数（LVMI）的关系。方法本研究共纳入82例IDA诊断标准符合标准的IDA患者。在这些患者中，有65个报告了LVMI值。随后，根据LVMI异常（男性> 115 g / m2，女性> 95 g / m2）将这些患者分为两组。进行线性双变量分析以检测血红蛋白或TIBC与临床和超声心动图特征的关系。简单线性回归分析用于评估LVMI与IDA参数之间的相关性，而多变量线性分析用于评估LVMI与年龄，TIBC和血红蛋白的相关性。使用逻辑回归分析确定左室重塑与贫血严重程度和TIBC的关系。结果与对照组相比，LVMI异常组TIBC水平升高。使用对数转换的LVMI作为因变量，同时将年龄，TIBC和血红蛋白引入简单的线性回归或多元线性回归分析中，证实了这些因素之间的正相关。双变量相关分析揭示了血红蛋白和TIBC之间的不相关性。在逻辑回归分析中，TIBC与左室重塑的风险有关。结论研究结果表明，在铁缺乏性贫血患者中，TIBC与LVMI有明确的关联。Logistic分析进一步证实了TIBC对IDA人群中LVMI异常发生的贡献。