Heat stress (HS) causes serious physiological dysfunction associated with cardiovascular diseases. Curcumin (CUR) may increase animal survival and lifespan under HS. However, its effects and mechanism on mammal are underexplored. The goal of this study was to examine the protective effect of CUR on the cardiac health of mice exposed to HS. Mice were divided into six groups (n=8 per group): no-heat treatment (NHT), heat treatment (HT), aspirin, CUR 50 mg/kg/day, CUR 100 mg/kg/day and CUR 200 mg/kg/day. After administration for 4 weeks, except for NHT, other groups were exposed once to HS at 41°C for 20 min. After HS treatment, the physiological-related indexes of blood pressure, rectal temperature and heart rate were measured. Serum biochemical indexes and the levels of cardiac troponin I (cTn-I) in serum and angiotensin II (Ang II) in cardiomyocytes were analyzed. Furthermore, the mRNA and proteins levels of angiotensin receptor 1 (AT1), 78-kDa glucose-regulated protein (GRP78), C/EBP homologous protein (CHOP) and B-cell lymphoma 2 (Bcl-2) were measured. Our results indicated that CUR supplementation could alleviate HS-induced physiological disorders and the increasing of cTn-I and Ang II. The expression of AT1 gene in HT group was significantly higher than that of CUR groups, indicating the cardioprotective effects of CUR. Moreover, the levels of GRP78 and CHOP proteins in the HT group were significantly higher than those of CUR groups, indicating that CUR supplementation reversed the endoplasmic reticulum HS-mediated apoptosis. In summary, CUR supplementation alleviates physiological stress and cardiac damage caused by HS.

热应激（HS）会导致与心血管疾病相关的严重生理功能障碍。姜黄素（CUR）可能会增加HS下的动物存活率和寿命。但是，其对哺乳动物的作用和机制尚未得到充分研究。这项研究的目的是检验CUR对暴露于HS的小鼠心脏健康的保护作用。将小鼠分为六组（n=每组8个）：无热处理（NHT），热处理（HT），阿司匹林，CUR 50 mg / kg /天，CUR 100 mg / kg /天和CUR 200 mg / kg /天。给药4周后，除NHT外，其他组均在41°C的HS中暴露20分钟。HS治疗后，测量血压，直肠温度和心率的生理相关指标。分析血清生化指标以及血清中心肌肌钙蛋白I（cTn-I）和心肌细胞中血管紧张素II（Ang II）的水平。此外，测量了血管紧张素受体1（AT1），78 kDa葡萄糖调节蛋白（GRP78），C / EBP同源蛋白（CHOP）和B细胞淋巴瘤2（Bcl-2）的mRNA和蛋白水平。我们的结果表明，补充CUR可以缓解HS引起的生理疾病以及cTn-I和Ang II的升高。表达HT组的AT1基因显着高于CUR组，说明CUR具有心脏保护作用。此外，HT组的GRP78和CHOP蛋白水平显着高于CUR组，表明补充CUR逆转了内质网HS介导的细胞凋亡。总之，CUR补充剂可减轻HS引起的生理压力和心脏损害。