Poly(D,L-lactide) microparticles impregnated with a number of bioactive paramagnetic compounds have been fabricated using two SCF techniques: 1). PGSS (Particles from Gas Saturated Solution) and 2). polymer plasticization and swelling by supercritical carbon dioxide followed by its cryomilling. Electron paramagnetic resonance (EPR) spectroscopy manifested homogeneous spatial distribution for the most of these substances encapsulated into the polymer. Irreversible relaxation processes in the prepared polymer structures and formulations were not observed. The qualitative difference in the release kinetics of paramagnetic molecules of different structure from the polymer microparticles into the phosphate-buffered saline (PBS, pH = 7.4) was demonstrated. pH-sensitive ATI spin probe proved the decrease (up to ≤ 4.5) of local pH inside the microparticles during the first 9 days after its immersion in PBS.

使用两种SCF技术已经制备了浸渍有多种生物活性顺磁性化合物的聚（D，L-丙交酯）微粒：1）。PGSS（气体饱和溶液中的颗粒）和2）。聚合物的增塑和超临界二氧化碳的溶胀，然后进行冷冻研磨。电子顺磁共振（EPR）光谱显示大多数包裹在聚合物中的物质均一的空间分布。在制备的聚合物结构和配方中未观察到不可逆的松弛过程。证明了结构不同的顺磁性分子从聚合物微粒释放到磷酸盐缓冲盐水（PBS，pH = 7.4）中的释放动力学的质量差异。pH敏感的ATI旋转探针证明了这种降低（最多≤4。