As a new, emerging class in catalysis field, single-atomic-site catalysts (SASCs) have displayed outstanding activities, selectivities, and stabilities in a range of important catalytic reactions. The compositions and structures of SASCs have a great impact on catalytic performances; therefore, the central task is to rationally manipulate the structures with atomic-level precision, and thereupon to design different active sites to promote the overall performances. Here, we compare SASCs with clusters/nanoparticles in term of their catalytic behaviors, and systematically interpret the impacts of the microscopic structures of SASCs on catalytic performances. Subsequently, we summarize the reports on synergistic catalysis over diatomic, multiatomic sites, single-atom alloys, and atomic interfaces, and highlight the great significance of in situ characterization technologies for monitoring the active sites. Finally, we discuss the limitations, development trends, and future challenges of SASCs, and present an outlook on further constructing more sophisticated active sites for more complex catalytic reactions.

作为催化领域中一个新兴的新兴类别，单原子中心催化剂（SASC）在一系列重要的催化反应中显示出出色的活性，选择性和稳定性。SASC的组成和结构对催化性能有很大的影响。因此，中心任务是合理地以原子级的精度操纵结构，然后设计不同的活性位点以提高整体性能。在这里，我们将SASCs与团簇/纳米颗粒的催化行为进行比较，并系统地解释SASCs的微观结构对催化性能的影响。随后，我们总结了有关在双原子，多原子位点，单原子合金和原子界面上协同催化的报道，并强调了其重要意义。用于监控活动站点的原位表征技术。最后，我们讨论了SASC的局限性，发展趋势和未来的挑战，并对进一步构建更复杂的活性位点以进行更复杂的催化反应提出了展望。