Six new compounds including two azaphilones, lunatoic acids D–E (1, 2), three isocoumarins, lunatinins B–D (3-5), and one α-pyrone derivative, lunatinin E (6), as well as four known ones, lunatoic acid A (7), lunatinin (8), penicipyran D (9) and chaetoquadrin F (10) were isolated from the rice medium of the gut fungus Paraphaeosphaeria sp. XZD2-1. Their planar structures were elucidated by analysis of 1D and 2D NMR as well as HRESIMS spectroscopic data. The absolute configurations of compounds 1-3 were assigned by experimental and calculated ECD data and an ester hydrolysis reaction. Compounds 4 and 5 were a pair of enantiomeric excess mixture. Structure of compound 6 was further confirmed by comparing optical rotation with known compounds according to literature. The antimicrobial activity and cytotoxicity of compounds 1-10 were examined.

六个新的化合物，包括2个azaphilones，lunatoic酸d-E（1，2），三个异香豆素，lunatinins B-d（3 - 5），以及一个α吡喃酮衍生物，lunatinin E（6），以及四个已知那些从肠道真菌Paraphaeosphaeria sp。的水稻培养基中分离到了lunatoic acid A（7），lunatinin（8），penicipyran D（9）和chaetoquadrin F（10）。XZD2-1。通过分析1D和2D NMR以及HRESIMS光谱数据，阐明了它们的平面结构。化合物的绝对构型1 - 3通过实验和计算得到的ECD数据和酯水解反应分配。化合物4和5是一对对映体过量混合物。根据文献，通过将旋光度与已知化合物进行比较，进一步证实了化合物6的结构。抗微生物活性和化合物的细胞毒性1 - 10进行了检查。