Repeat-associated non-ATG (RAN) translation is emerging as a driver of pathogenesis in microsatellite expansion disorders. Green and colleagues recently identified several candidate RAN translation inhibitors from a high-throughput small-molecule screen for fragile X tremor ataxia syndrome. Their study establishes a path forward for identifying inhibitors of RAN translation for multiple disorders.

中文翻译：

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毒品筛查拖轮在通用线程上出现重复性疾病。

重复相关的非ATG（RAN）翻译正在成为微卫星扩展疾病发病机理的驱动因素。Green及其同事最近从高通量小分子筛查中确定了几种易碎X震颤共济失调综合症候选RAN翻译抑制剂。他们的研究为鉴定多种疾病的RAN翻译抑制剂提供了一条途径。