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Anti-diabetic drugs recent approaches and advancements.
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-01-08 , DOI: 10.1016/j.bmc.2019.115263 Jayanta Dowarah 1 , Ved Prakash Singh 1
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-01-08 , DOI: 10.1016/j.bmc.2019.115263 Jayanta Dowarah 1 , Ved Prakash Singh 1
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Diabetes is one of the major diseases worldwide and is the third leading cause of death in the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control glucose levels in the blood. Most of the drugs are administered orally, except for a few of them, such as insulin, exenatide, and pramlintide. In this review, we are going to discuss seven major types of anti-diabetic drugs: Peroxisome proliferator-activated receptor (PPAR) agonist, protein tyrosine phosphatase 1B (PTP1B) inhibitors, aldose reductase inhibitors, α-glucosidase inhibitors, dipeptidyl peptidase IV (DPP-4) inhibitors, G protein-coupled receptor (GPCR) agonists and sodium-glucose co-transporter (SGLT) inhibitors. Here, we are also discussing some of the recently reported anti-diabetic agents with its multi-target pharmacological actions. This review summarises recent approaches and advancement in anti-diabetes treatment concerning characteristics, structure-activity relationships, functional mechanisms, expression regulation, and applications in medicine.
中文翻译：
抗糖尿病药物的最新方法和进展。
糖尿病是世界范围内的主要疾病之一，并且是美国第三大死亡原因。抗糖尿病药用于治疗糖尿病，以控制血液中的葡萄糖水平。除少数药物（如胰岛素，艾塞那肽和普兰林肽）外，大多数药物都是口服给药。在这篇综述中，我们将讨论七种主要的抗糖尿病药物：过氧化物酶体增殖物激活受体（PPAR）激动剂，蛋白酪氨酸磷酸酶1B（PTP1B）抑制剂，醛糖还原酶抑制剂，α-葡萄糖苷酶抑制剂，二肽基肽酶IV（ DPP-4）抑制剂，G蛋白偶联受体（GPCR）激动剂和钠葡萄糖共转运蛋白（SGLT）抑制剂。在这里，我们还讨论了一些最近报道的具有多靶点药理作用的抗糖尿病药。
更新日期：2020-01-08
中文翻译：
抗糖尿病药物的最新方法和进展。
糖尿病是世界范围内的主要疾病之一，并且是美国第三大死亡原因。抗糖尿病药用于治疗糖尿病，以控制血液中的葡萄糖水平。除少数药物（如胰岛素，艾塞那肽和普兰林肽）外，大多数药物都是口服给药。在这篇综述中，我们将讨论七种主要的抗糖尿病药物：过氧化物酶体增殖物激活受体（PPAR）激动剂，蛋白酪氨酸磷酸酶1B（PTP1B）抑制剂，醛糖还原酶抑制剂，α-葡萄糖苷酶抑制剂，二肽基肽酶IV（ DPP-4）抑制剂，G蛋白偶联受体（GPCR）激动剂和钠葡萄糖共转运蛋白（SGLT）抑制剂。在这里，我们还讨论了一些最近报道的具有多靶点药理作用的抗糖尿病药。
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