The generation of stabilized supramolecular nanorods from star-shaped polyglutamates,Polymer Chemistry

当前位置： X-MOL 学术 › Polym. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The generation of stabilized supramolecular nanorods from star-shaped polyglutamates
Polymer Chemistry ( IF 4.1 ) Pub Date : 2020/01/08 , DOI: 10.1039/c9py01442j
O. Zagorodko _{1,

2,

3} , V. J. Nebot _{1,

2,

3} , M. J. Vicent _{1,

2,

3}

Affiliation

We developed a new strategy of polyglutamate nanorod preparation based on supramolecular polymers stabilized with hydrophobic drugs. Using this strategy, we prepared a family of star-shaped polyglutamates (star-PGAs) with benzenetricarboxamide (BTA)-based cores of different hydrophobicity. We then studied the self-assembly of the resulting polymers in aqueous solutions containing a physiological level of salt using fluorescence spectroscopy, small-angle X-ray scattering (SAXS), and transmission electron microscopy (TEM). We discovered that star-PGAs behave as classical polyelectrolytes in very dilute solutions; however, compounds with hydrophobic cores assembled into one dimensional-nanorods upon an increase in concentration due to supramolecular interactions in the core. Small hydrophobic drugs, such as doxorubicin and irinotecan, stabilized the nanorods and inhibited their disassembly at concentrations below the critical aggregation concentration (CAC). We anticipate that this simple nanorod preparation strategy from star-PGAs will enable the development of new nanomedicines with unique biodistribution profiles and biological activity.

中文翻译：

从星形聚谷氨酸生成稳定的超分子纳米棒

我们开发了一种基于疏水性药物稳定的超分子聚合物制备聚谷氨酸纳米棒的新策略。使用这种策略，我们制备了一系列具有不同疏水性的苯三甲酰胺（BTA）基核的星形聚谷氨酸酯（star-PGA）。然后，我们使用荧光光谱法，小角X射线散射（SAXS）和透射电子显微镜（TEM）研究了在含生理水平盐的水溶液中所得聚合物的自组装。我们发现，在非常稀的溶液中，星形-PGA的行为就像传统的聚电解质一样。然而，由于核中的超分子相互作用，随着浓度的增加，具有疏水性核的化合物会组装成一维-纳米级。小型疏水性药物，例如阿霉素和伊立替康在低于临界聚集浓度（CAC）的浓度下，可稳定纳米棒并抑制其分解。我们预计，星型PGA的这种简单的纳米棒制备策略将使具有独特的生物分布特征和生物活性的新型纳米药物的开发成为可能。

更新日期：2020-02-13

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11