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Recent trends in catalytic sp3 C-H functionalization of heterocycles.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-01-08 , DOI: 10.1039/c9ob01559k
Milanpreet Kaur 1 , Jeffrey F Van Humbeck 1
Affiliation  

Heterocycles are a ubiquitous substructure in organic small molecules designed for use in materials and medicines. Recent work in catalysis has focused on enabling access to new heterocycle structures by sp3 C-H functionalization on alkyl side-chain substituents-especially at the heterobenzylic position-with more than two hundred manuscripts published just within the last ten years. Rather than describing in detail each of these reports, in this mini-review we attempt to highlight gaps in existing techniques. A semi-quantitative overview of ongoing work strongly suggests that several specific heterocycle types and bond formations outside of C-C, C-N, and C-O have been almost completely overlooked.

中文翻译:

杂环催化sp3 CH功能化的最新趋势。

杂环是有机小分子中普遍存在的亚结构,旨在用于材料和药物。最近的催化工作集中在通过在烷基侧链取代基上的sp3 CH官能化(特别是在杂苄基位置上)获得新的杂环结构上,仅在最近十年中发表了200多份手稿。在此小型回顾中,我们没有详细描述每个报告,而是尝试强调现有技术中的差距。对正在进行的工作进行的半定量概述强烈表明,CC,CN和CO之外的几种特定的杂环类型和键的形成几乎被完全忽略了。
更新日期:2020-02-12
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