A male patient in his 70s presented an asymptomatic, slightly eroded, translucent nodule on his right nipple (Figure, A). There was a family history of cutaneous melanoma in his 2 sisters, daughter, and nephew and breast cancer in his mother and sister. We completed genetic testing of family members and found no genetic mutations in sera samples to predispose them to melanoma skin cancer or breast cancer. The main genes tested were the breast cancer type 1 susceptibility (BRCA1), breast cancer 2–DNA repair associated (BRCA2), partner and localizer of BRCA2 (PALB2), checkpoint kinase 2 (CHEK2), and tumor protein p53 (TP53) genes. A dermoscopic examination of the patient showed a translucent lesion with arborizing vessels and erosion (Figure, B). A punch biopsy was performed.

一位70多岁的男性患者的右乳头呈现出无症状，轻微侵蚀的半透明结节（图A）。他的两个姐妹，女儿以及他的母亲和妹妹的侄子和乳腺癌都有家族性皮肤黑色素瘤病史。我们完成了对家庭成员的基因测试，发现血清样本中没有基因突变，使他们容易患黑色素瘤，皮肤癌或乳腺癌。测试的主要基因是乳腺癌1型敏感性（BRCA1），乳腺癌2-DNA修复有关（BRCA2），的合作伙伴和定位器BRCA2（PALB2），检查点激酶2（CHEK2）和肿瘤p53蛋白（TP53）基因。病人的皮肤镜检查显示有半透明的病变，带有树状血管和糜烂（图B）。进行打孔活检。