The aim of the study was to evaluate the effect of dietary supplementation with chosen minerals (Zn, Se, Fe) on expression of selected cytokines (IL-1, IL-6, TNFα) in spleen of rats and on their concentrations in rat serum under inflammatory and pathological conditions obtained by implantation of prostate cancer cells (LnCaP). Serum levels of metabolites of arachidonic, eicosapentaenoic and linoleic acids (hydroxyeicosatetraenoic, hydroxyeicosapentaenoic and hydroxyoctadecadienoic acids, respectively), as compounds involved in inflammation and cancer development, were also investigated. Male rats were randomised into dietary groups supplemented with Zn, Se or Fe. Prostate cancer cells were implanted to some rats in each group. The study demonstrated that minerals supplemented with the diet may exert various effects on an organism. Selenium, zinc and iron influence pro-inflammatory cytokine expression, what leads to stimulation of inflammation. They also affect synthesis of arachidonic and linoleic acid metabolites that exert pro-inflammatory action and enable cancer development and metastasis.

中文翻译：

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癌症中的炎症因子和元素补充。

这项研究的目的是评估膳食中添加选定矿物质（锌，硒，铁）对大鼠脾脏中所选细胞因子（IL-1，IL-6，TNFα）的表达及其在大鼠血清中的浓度的影响。在通过植入前列腺癌细胞（LnCaP）获得的炎症和病理条件下。还研究了血清花生四烯酸，二十碳五烯酸和亚油酸（分别为羟基二十碳四烯酸，羟基二十碳五烯酸和羟基十八碳二烯酸）的代谢产物，它们与炎症和癌症的发展有关。将雄性大鼠随机分为补充锌，硒或铁的饮食组。前列腺癌细胞被植入每组的一些大鼠中。研究表明，补充饮食的矿物质可能对生物体产生各种影响。硒，锌和铁会影响促炎细胞因子的表达，从而导致炎症的刺激。它们还影响花生四烯酸和亚油酸代谢产物的合成，这些代谢产物具有促炎作用并能促进癌症的发展和转移。