OBJECTIVES To assess the association between low muscle mass and osteoporosis in the Korean general population. METHODS We analyzed 14,429 participants (6,261 men and 8,168 women) from the 2009-2011 Korean National Health and Nutrition Examination Survey (KNHANES) aged 20 years or more. MAIN OUTCOME MEASURE The association of low muscle mass with osteoporosis was investigated using multivariate logistic regression models that included age, marital status, residence, current smoking, monthly drinking, physical activities, strength exercise, comorbidity, and the use of dietary supplements, and in women postmenopausal status and experience of pregnancy. RESULTS After adjusting for covariates, low muscle mass was significantly associated with osteoporosis in the lumbar spine and femoral neck in both men (lumbar spine: OR 1.73, 95 % CI 1.08-2.76; femoral neck: OR 3.39, 95 % CI 1.69-6.80) and women (lumbar spine: OR 1.52, 95 % CI 1.17-1.97; femoral neck: OR 2.09, 95 % CI 1.56-2.80). Also, the association between low muscle mass and osteoporosis was significant in men and women in every age group except for men aged 50-64 years. CONCLUSION Low muscle mass was significantly associated with osteoporosis in both men and women for all age groups, except for men aged 50-64 years.

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低肌肉质量与骨质疏松症有关：一项全国性的基于人群的研究

目的 评估韩国一般人群中低肌肉量与骨质疏松症之间的关联。方法 我们分析了 2009-2011 年韩国国家健康和营养检查调查 (KNHANES) 中年龄在 20 岁或以上的 14,429 名参与者（6,261 名男性和 8,168 名女性）。主要结果测量使用多变量逻辑回归模型研究低肌肉质量与骨质疏松症的关联，模型包括年龄、婚姻状况、居住地、当前吸烟、每月饮酒、体育活动、力量锻炼、合并症和膳食补充剂的使用，以及妇女绝经后状态和怀孕经历。结果 调整协变量后，低肌肉质量与男性腰椎和股骨颈骨质疏松症显着相关（腰椎：OR 1.73，95 % CI 1.08-2.76；股骨颈：OR 3.39，95 % CI 1.69-6.80）和女性（腰椎：OR 1.52，95 % CI 1.17-1.97；股骨颈：OR 2.09，95 % CI 1.56-2.80）。此外，除了 50-64 岁的男性外，所有年龄组的男性和女性的低肌肉质量和骨质疏松症之间的关联都很显着。结论 除 50-64 岁男性外，所有年龄组男性和女性的低肌肉质量与骨质疏松症显着相关。