Fungal infections induced by Candida albicans have increased worldwide due to emerging resistance to antifungal agents, which is largely caused by biofilm formation. Thus, a new and effective antimicrobial strategy is urgently required in treatment of C. albicans biofilm‐associated infections. In this study, the inactivation effects of cold plasma treatment for C. albicans biofilm are assessed in vitro and in vivo. In vitro studies indicate that C. albicans in suspension and the C. albicans biofilm are inactivated significantly by plasma treatment. In vivo studies indicate that plasma treatment achieves the best antifungal effect with an optimal dose (4 min in this case), as excessive plasma treatment damages the normal tissues and thus induces aggravation of infection compared to the 4‐min group.

中文翻译：

---

体外和体内冷血浆处理可灭活白色念珠菌生物膜

由于新出现的抗真菌剂耐药性，白色念珠菌引起的真菌感染在全球范围内增加，这主要是由于生物膜的形成。因此，迫切需要一种新的有效的抗菌策略来治疗白色念珠菌生物膜相关感染。在这项研究中，在体外和体内评估了冷等离子体处理对白色念珠菌生物膜的灭活作用。体外研究表明，白色念珠菌悬浮液和 白色念珠菌生物膜通过等离子体处理显着失活。体内研究表明，血浆治疗以最佳剂量（本例中为4分钟）达到最佳的抗真菌作用，因为与4分钟组相比，过多的血浆治疗会损害正常组织并因此导致感染加重。