Poor old pores-The challenge of making and maintaining nuclear pore complexes in aging.,The FEBS Journal

当前位置： X-MOL 学术 › FEBS J. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Poor old pores-The challenge of making and maintaining nuclear pore complexes in aging.
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-01-08 , DOI: 10.1111/febs.15205
Irina L Rempel ₁ , Anton Steen ₁ , Liesbeth M Veenhoff ₁

Affiliation

The nuclear pore complex (NPC) is the sole gateway to the nuclear interior, and its function is essential to all eukaryotic life. Controlling the functionality of NPCs is a tremendous challenge for cells. Firstly, NPCs are large structures, and their complex assembly does occasionally go awry. Secondly, once assembled, some components of the NPC persist for an extremely long time and, as a result, are susceptible to accumulate damage. Lastly, a significant proportion of the NPC is composed of intrinsically disordered proteins that are prone to aggregation. In this review, we summarize how the quality of NPCs is guarded in young cells and discuss the current knowledge on the fate of NPCs during normal aging in different tissues and organisms. We discuss the extent to which current data supports a hypothesis that NPCs are poorly maintained during aging of nondividing cells, while in dividing cells the main challenge is related to the assembly of new NPCs. Our survey of current knowledge points toward NPC quality control as an important node in aging of both dividing and nondividing cells. Here, the loss of protein homeostasis during aging is central and the NPC appears to both be impacted by, and to drive, this process.

中文翻译：

旧毛孔差-在老化过程中制造和维护核孔复合物的挑战。

核孔复合体（NPC）是通向核内部的唯一通道，其功能对于所有真核生物都是必不可少的。对于细胞而言，控制NPC的功能是一项巨大的挑战。首先，NPC是大型结构，其复杂的装配有时会出现问题。其次，一旦组装，NPC的某些组件将保留很长时间，因此很容易累积损坏。最后，很大一部分的NPC由易于聚集的内在无序蛋白组成。在这篇综述中，我们总结了如何在年轻细胞中保护NPC的质量，并讨论了当前有关不同组织和生物体正常衰老过程中NPC命运的知识。我们讨论了当前数据在多大程度上支持以下假设：在不分裂细胞的衰老过程中，NPC的维持能力很差，而在分裂细胞中，主要挑战与新NPC的组装有关。我们对当前知识的调查表明，NPC质量控制是分裂和非分裂细胞老化的重要节点。在这里，衰老过程中蛋白质稳态的丧失是至关重要的，而NPC似乎既受该过程的影响，又推动该过程。

更新日期：2020-03-16

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文