Crosslinked, biodegradable polyurethanes for precision‐porous biomaterials: Synthesis and properties,Journal of Applied Polymer Science

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Crosslinked, biodegradable polyurethanes for precision‐porous biomaterials: Synthesis and properties
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-01-08 , DOI: 10.1002/app.48943
Erasmo Lopez Calleros ₁ , Felix I. Simonovsky ₁ , Shai Garty ₁ , Buddy D. Ratner _{1,

2}

Affiliation

Crosslinked poly(ester urethane)s and their acrylate derivatives based on trifunctional polycaprolactone and trifunctional aliphatic isocyanates were synthesized. Biodegradable scaffolds with uniform, controlled micron‐scale porosity were fabricated with these materials. Mechanical and swelling properties of monolithic and microporous materials were studied. Cytotoxicity, hydrolytic, and enzymatic degradation and their effects on mechanical properties of the biodegradable scaffolds were investigated. The polymer degradation products were found not to be cytotoxic at moderate concentrations and to permit cell attachment and spreading. Degradation rates and mechanical properties could be tuned to desired performance criteria for a given application by adjusting crosslink density and the ratio of hard segment to soft segment. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48943.

中文翻译：

精密多孔生物材料的可生物降解的交联聚氨酯：合成与性能

合成了基于三官能聚己内酯和三官能脂族异氰酸酯的交联聚（酯氨基甲酸酯）及其丙烯酸酯衍生物。用这些材料制造了具有均匀，可控制的微米级孔隙率的可生物降解支架。研究了整体和微孔材料的力学和溶胀性能。研究了细胞毒性，水解和酶促降解及其对可生物降解支架的机械性能的影响。发现该聚合物降解产物在中等浓度下没有细胞毒性，并且可以使细胞附着和扩散。通过调节交联密度和硬链段与软链段的比例，可以将降解速率和机械性能调整到给定应用所需的性能标准。©2019 Wiley期刊，Inc.J.Appl。Polym。科学2020，137，48943。

更新日期：2020-03-26

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