BACKGROUND Both serum homocysteine and high sensitivity C - reactive protein (hsCRP) are inflammatory markers related to vascular aging. Little was known about relationship between hsCRP and homocysteine and sarcopenia. The study aimed to explore the association between these two biomarkers and sarcopenia and its components. METHODS Data of 1582 participants excerpted from first wave of I-Lan Longitudinal Aging Study. Sarcopenia was defined according to criteria of the Asian Working Group of Sarcopenia. Logistic regression was employed to examine the aforementioned associations. RESULTS High levels of homocysteine (OR 1.9, 95% CI 1.0-3.6) and hsCRP (OR 3.9, 95% CI 2.2-6.9) were independently associated with sarcopenia. Both biomarkers were significantly associated with weakness (OR 2.9, 95%CI 2.1-4.0 for high level of homocysteine; OR 1.6, 95% CI 1.2-2.0 for high level of hsCRP) and slowness (OR 2.0, 95%CI 1.3-3.0 for high level of homocysteine; OR1.5, 95% CI1.1-2.2 for high level of hsCRP). Stronger associations between high levels of homocysteine and sarcopenia were noted in the women. CONCLUSION The study confirmed positive association between homocysteine, hsCRP and sarcopenia and further highlighted potential roles of both biomarkers in sarcopenia development. Intervention studies are needed to evaluate potential therapeutic benefits of lowering homocysteine and hsCRP in managing sarcopenia.

中文翻译：

---

血清同型半胱氨酸，高敏C反应蛋白和肌肉减少症之间的性别差异关联：I-Lan纵向衰老研究的结果。

背景技术血清高半胱氨酸和高敏感性C反应蛋白（hsCRP）都是与血管衰老相关的炎症标志物。关于hsCRP与同型半胱氨酸和少肌症之间的关系知之甚少。该研究旨在探讨这两种生物标志物与肌肉减少症及其组成部分之间的关​​联。方法1582名参与者的数据摘自I-Lan纵向老龄化研究的第一波。肌肉减少症是根据亚洲肌肉减少症工作组的标准定义的。采用逻辑回归分析上述关联。结果高水平的半胱氨酸（OR 1.9，95％CI 1.0-3.6）和hsCRP（OR 3.9，95％CI 2.2-6.9）与肌肉减少症独立相关。两种生物标志物均与弱点显着相关（OR 2.9，高半胱氨酸水平为95％CI 2.1-4.0； OR 1.6，高水平的hsCRP为95％CI 1.2-2.0）和慢度（高水平的半胱氨酸为OR 2.0，高半胱氨酸为95％CI 1.3-3.0;高水平的hsCRP为OR1.5,95％CI1.1-2.2）。妇女中高半胱氨酸水平和肌肉减少症之间的关联性更强。结论该研究证实了同型半胱氨酸，hsCRP与少肌症之间存在正相关，并进一步强调了这两种生物标记物在少肌症发展中的潜在作用。需要进行干预研究来评估降低同型半胱氨酸和hsCRP在减少肌肉减少症中的潜在治疗作用。结论该研究证实了同型半胱氨酸，hsCRP与少肌症之间存在正相关，并进一步强调了这两种生物标记物在少肌症发展中的潜在作用。需要进行干预研究来评估降低同型半胱氨酸和hsCRP在减少肌肉减少症中的潜在治疗作用。结论该研究证实了同型半胱氨酸，hsCRP与少肌症之间存在正相关，并进一步强调了这两种生物标记物在少肌症发展中的潜在作用。需要进行干预研究来评估降低同型半胱氨酸和hsCRP在减少肌肉减少症中的潜在治疗作用。