Influenza A(H1N1)pdm09 (pH1N1) virus has become established in swine in the United Kingdom and currently co-circulates with previously enzootic swine influenza A virus (IAV) strains, including avian-like H1N1 and human-like H1N2 viruses. During 2010, a swine influenza A reassortant virus, H1N2r, which caused mild clinical disease in pigs in the United Kingdom, was isolated. This reassortant virus has a novel gene constellation, incorporating the internal gene cassette of pH1N1-origin viruses and hemagglutinin and neuraminidase genes of swine IAV H1N2 origin. We investigated the pathogenesis and infection dynamics of the H1N2r isolate in pigs (the natural host) and in ferrets, which represent a human model of infection. Clinical and virologic parameters were mild in both species and both intraspecies and interspecies transmission was observed when initiated from either infected pigs or infected ferrets. This novel reassortant virus has zoonotic and reverse zoonotic potential, but no apparent increased virulence or transmissibility, in comparison to pH1N1 viruses.

中文翻译：

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包含来自猪流感A（H1N1）pdm09和A（H1N2）病毒基因的重组猪A型流感病毒的种间传播。

甲型流感（H1N1）pdm09（pH1N1）病毒已在英国的猪中建立，目前与以前的流行性甲型流感A病毒（IAV）菌株（包括禽样H1N1和人样H1N2病毒）一起传播。2010年期间，分离出了在英国引起猪的轻度临床疾病的甲型流感甲型流感病毒H1N2r。这种重配病毒具有新颖的基因构象，整合了pH1N1起源病毒的内部基因盒以及猪IAV H1N2起源的血凝素和神经氨酸酶基因。我们调查了H1N2r分离株在猪（天然宿主）和雪貂中的发病机理和感染动力学，它们代表了人类感染模型。在两个物种中，临床和病毒学参数均较轻，当从受感染的猪或受感染的雪貂开始时，均观察到种内和种间传播。与pH1N1病毒相比，这种新型重配病毒具有人畜共患和逆向人畜共患的潜力，但毒力或传播性没有明显增加。