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Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection.
Emerging Infectious Diseases ( IF 7.2 ) Pub Date : 2020-02-01 , DOI: 10.3201/eid2602.190434
Kelly E. Coller , Veronica Bruce , Michael Cassidy , Jeffrey Gersch , Matthew B. Frankel , Ana Vallari , Gavin Cloherty , John Hackett , Jennifer L. Evans , Kimberly Page , George J. Dawson

Most human pegivirus 2 (HPgV-2) infections are associated with past or current hepatitis C virus (HCV) infection. HPgV-2 is thought to be a bloodborne virus: higher prevalence of active infection has been found in populations with a history of parenteral exposure to viruses. We evaluated longitudinally collected blood samples obtained from injection drug users (IDUs) for active and resolved HPgV-2 infections using a combination of HPgV-2-specific molecular and serologic tests. We found evidence of HPgV-2 infection in 11.2% (22/197) of past or current HCV-infected IDUs, compared with 1.9% (4/205) of an HCV-negative IDU population. Testing of available longitudinal blood samples from HPgV-2-positive participants identified 5 with chronic infection (>6 months viremia in >3 timepoints); 2 were identified among the HCV-positive IDUs and 3 among the HCV-negative IDUs. Our findings indicate that HPgV-2 can establish chronic infection and replicate in the absence of HCV.

中文翻译:

无丙型肝炎病毒共感染的慢性人类Pegivirus 2。

大多数人类pegivirus 2(HPgV-2)感染与过去或当前的丙型肝炎病毒(HCV)感染相关。HPgV-2被认为是一种血源性病毒:在有肠胃外接触病毒史的人群中发现主动感染的患病率更高。我们结合使用HPgV-2特异性分子和血清学检测方法,评估了从注射吸毒者(IDU)获得的纵向采集的血液样本中是否存在活跃和已解决的HPgV-2感染。我们发现,过去或当前感染HCV的IDU中有11.2%(22/197)感染HPgV-2的证据,而HCV阴性IDU人群中有1.9%(4/205)。对来自HPgV-2阳性参与者的可用纵向血液样本进行测试,发现5例患有慢性感染(在3个以上的时间点中病毒血症> 6个月);在HCV阳性IDU中鉴定出2个,在HCV阴性IDU中鉴定出3个。我们的发现表明,HPgV-2可以建立慢性感染并在没有HCV的情况下复制。
更新日期:2020-01-21
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