PURPOSE To investigate whether cornea verticillata affects corneal topography, tomography, densitometry, or biomechanics of Fabry patients with ocular manifestations and to compare these results with those obtained from healthy subjects. METHODS This prospective, cross-sectional study included 23 Fabry patients (Fabry group) with cornea verticillata and the 37 age- and sex-matched healthy subjects (control group). After comprehensive ophthalmological examinations, corneal topography, tomography, and densitometry measurements were taken using Pentacam HR and corneal biomechanics were captured via Corvis ST for all participants. RESULTS All the investigated topographic and tomographic values were similar in the eyes with Fabry disease (FD) and the controls (P > 0.05). The corneal densitometry values of patients with FD were statistically significantly higher in all the concentric zones and layers, except posterior 0-2 mm and posterior 2-6 mm zones, compared to the controls (P < 0.05). The mean values of A1 velocity, A2 velocity, deformation amplitude ratio, Corvis biomechanical index, tomographic and biomechanical index, and Stiffness parameter at the first applanation in the Fabry group were statistically significantly different compared to control group (P < 0.05). However, the mean values of A1 length, A2 length, and the biomechanically corrected intraocular pressure were similar between the groups (P = 0.317, P = 0.819, and P = 0.468; respectively). CONCLUSION Although cornea verticillata associated with FD is not considered to affect vision, it is associated with increased light backscattering and reduced corneal transparency as well as altered corneal biomechanical properties.

中文翻译：

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评估具有眼部表现的法布里患者的角膜地形图，断层扫描，光密度和生物力学特性。

目的调查角膜黄斑是否会影响具有眼部表现的法布里患者的角膜地形图，断层扫描，光密度测定或生物力学，并将这些结果与从健康受试者获得的结果进行比较。方法这项前瞻性，横断面研究包括23名法布里患者（法布里组）患有角膜网膜炎和37名年龄和性别相匹配的健康受试者（对照组）。经过全面的眼科检查后，使用Pentacam HR进行角膜地形图，断层扫描和光密度测定，并通过Corvis ST为所有参与者采集角膜生物力学。结果在法布里病（FD）和对照组中，所有调查的地形和断层扫描值均相似（P> 0.05）。与对照组相比，除后部0-2 mm和后部2-6 mm区域外，在所有同心区和层中，FD患者的角膜密度测定值在统计学上均显着较高（P <0.05）。在法布里组的第一压平处，A1速度，A2速度，变形幅度比，Corvis生物力学指数，断层显像和生物力学指数以及刚度参数的平均值与对照组相比有统计学差异（P <0.05）。但是，两组之间的A1长度，A2长度和经生物力学校正的眼压的平均值相似（分别为P = 0.317，P = 0.819和P = 0.468）。结论尽管与FD相关的角膜网状黄斑并不被认为会影响视力，