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Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review.
International Journal of Oral Science ( IF 10.8 ) Pub Date : 2020-01-02 , DOI: 10.1038/s41368-019-0068-8 Ran Cheng 1 , Zhiwu Wu 1 , Mingming Li 1 , Meiying Shao 2 , Tao Hu 1
International Journal of Oral Science ( IF 10.8 ) Pub Date : 2020-01-02 , DOI: 10.1038/s41368-019-0068-8 Ran Cheng 1 , Zhiwu Wu 1 , Mingming Li 1 , Meiying Shao 2 , Tao Hu 1
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Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.
中文翻译：
白细胞介素 1β 是牙周炎的潜在治疗靶点：叙述性综述。
白细胞介素 (IL)-1β 是一种促炎细胞因子，升高并参与牙周炎。不仅IL-1β与牙周炎之间的联系被临床证据证明，而且IL-1β的升高引发了一系列炎症反应，促进了骨吸收。目前，IL-1β阻断已成为自身免疫和自身炎症性疾病的治疗策略，如类风湿性关节炎、冷冻吡啶相关的周期性综合征、痛风和II型糖尿病。推测IL-1β是牙周炎的潜在治疗靶点。这篇综述着重于牙周炎中 IL-1β 的产生、机制、目前的治疗方法和未来的潜在策略。
更新日期：2020-01-02
中文翻译：
白细胞介素 1β 是牙周炎的潜在治疗靶点：叙述性综述。
白细胞介素 (IL)-1β 是一种促炎细胞因子，升高并参与牙周炎。不仅IL-1β与牙周炎之间的联系被临床证据证明，而且IL-1β的升高引发了一系列炎症反应，促进了骨吸收。目前，IL-1β阻断已成为自身免疫和自身炎症性疾病的治疗策略，如类风湿性关节炎、冷冻吡啶相关的周期性综合征、痛风和II型糖尿病。推测IL-1β是牙周炎的潜在治疗靶点。这篇综述着重于牙周炎中 IL-1β 的产生、机制、目前的治疗方法和未来的潜在策略。
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