Phosphate metabolism is an evolving area of basic and clinical research. In the past 15 years, knowledge on disturbances of phosphate homoeostasis has expanded, as has the discovery of new targeted therapies. Hypophosphataemia might be the biochemical finding in several diseases, and its clinical evaluation should initially focus on the assessment of pathophysiological mechanisms leading to low serum phosphate concentrations. Clinical consequences of hypophosphataemia can involve multiple organ systems and vary depending on several factors, the most important being the underlying disorder. This Review focuses on the approach to patients with hypophosphataemia and how underlying pathophysiological mechanisms should be understood in the evaluation of differential diagnosis. We define an algorithm for the assessment of hypophosphataemia and review the most up-to-date literature on specific therapies. Continuous research in this area will result in a better understanding and management of patients with hypophosphataemia.

中文翻译：

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低磷血症患者的治疗方法。

磷酸盐代谢是基础和临床研究的一个不断发展的领域。在过去的15年中，关于磷酸盐同稳态干扰的知识以及新的靶向疗法的发现也得到了扩展。低磷血症可能是几种疾病的生化发现，其临床评估应首先侧重于评估导致血清磷酸盐浓度低的病理生理机制。低磷血症的临床后果可能涉及多个器官系统，并取决于多种因素，其中最重要的是潜在的疾病。这篇综述着重于低磷血症患者的治疗方法以及在鉴别诊断评估中应如何理解潜在的病理生理机制。我们定义了一种评估低磷血症的算法，并回顾了有关特定疗法的最新文献。在这一领域的不断研究将使低磷血症患者更好地了解和管理。