Gold Nanoclusters-Coated Orthodontic Devices Can Inhibit the Formation of Streptococcus mutans Biofilm,ACS Biomaterials Science & Engineering

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Gold Nanoclusters-Coated Orthodontic Devices Can Inhibit the Formation of Streptococcus mutans Biofilm
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-01-22 , DOI: 10.1021/acsbiomaterials.9b01647
Yangzhouyun Xie _{1,

2} , Mengqi Zhang ₃ , Wei Zhang ₂ , Xiaomo Liu ₃ , Wenfu Zheng ₂ , Xingyu Jiang _{1,

2}

Affiliation

Oral health is an issue that has attracted increasing attention recently. Poor oral hygiene may induce the formation of oral biofilm on orthodontic devices, and cause gingivitis and dental caries. Here, we present a strategy for modifying orthodontic devices (e.g., invisalign aligner) with quaternary ammonium (QA)-modified gold nanoclusters (QA-GNCs) as an antibiotic reagent to prevent bacterial contamination and biofilm formation. The QA-GNCs-coated aligner can efficiently inhibit the adhesion of cariogenic pathogenic Streptococcus mutans and the formation of biofilm. Moreover, the antibacterial activity of the coated QA-GNCs can be maintained for at least 3 months and after repeated usage (>3 cycles). Furthermore, the QA-GNCs coating shows excellent biosafety confirmed by the cell viability test, the hemolysis assay, and animal experiments. Our strategy for antibacterial coating has the advantages of broad applications, low cost, good stability, high antibacterial efficiency, good biocompatibility, and low risk of antibiotic contamination, which could be particularly useful in preventing infections involving implantable medical devices or wearable electronics.

中文翻译：

金纳米簇涂层的正畸设备可以抑制变形链球菌生物膜的形成。

口腔健康是最近引起越来越多关注的一个问题。不良的口腔卫生可能会导致在正畸器械上形成口腔生物膜，并引起牙龈炎和龋齿。在这里，我们提出了一种用季铵盐（QA）修饰的金纳米团簇（QA-GNCs）作为抗生素试剂来修饰正畸器械（例如，不粘牙对准器）的策略，以防止细菌污染和生物膜形成。QA-GNCs涂层对准剂可有效抑制致癌性致病性变形链球菌的粘附和生物膜的形成。此外，包被的QA-GNC的抗菌活性可以保持至少3个月，并且可以重复使用（> 3个循环）。此外，QA-GNCs涂层具有出色的生物安全性，并通过细胞生存力测试，溶血分析和动物实验得到证实。我们的抗菌涂层策略具有应用广泛，成本低，稳定性好，抗菌效率高，生物相容性好以及抗生素污染风险低的优点，这在预防涉及可植入医疗设备或可穿戴电子设备的感染方面尤其有用。

更新日期：2020-01-23

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