BACKGROUND Traditionally, wide lateral surgical margins of 3 cm and one fascial plane deep have been recommended for resection of canine cutaneous mast cell tumor (MCT). Several studies have been published assessing surgical margins of less than this traditional recommendation. The objective of this systematic review was to determine if resection MCT with lateral surgical margins < 3 cm results in low rates of incomplete resection and local tumor recurrence. Systematic searches of digital bibliographic databases were performed with two authors (AR & LES) screening abstracts to identify relevant scientific articles. Studies regarding surgical treatment of dogs with cutaneous MCT were reviewed. Data abstraction was performed and the quality of individual studies and the strength of the body of evidence for utilization of surgical margins < 3 cm for removal of MCTs was assessed. RESULTS From the initial 78 citations identified through the database searches, four articles were retained for data abstraction after both relevance screenings were performed. Two studies were retrospective observational studies, one was a prospective case series and one was a prospective clinical trial. Assessment of the quality level of the body of evidence identified using the GRADE system was low. Excision of MCT at 2 cm and 3 cm was associated with comparably low rates of incomplete excision and recurrence. CONCLUSIONS Despite the low quality of the overall body of evidence, a recommendation can be made that resection of canine cutaneous MCTs (< 4 cm) of Patnaik grade I and II with 2 cm lateral margins and 1 fascial plane deep results in low rates of incomplete excision and local tumor recurrence.

中文翻译：

---

对用于去除犬皮肤肥大细胞瘤的手术切缘的系统评价。

背景技术传统上，已经建议将3cm宽的侧向手术切缘和一个筋膜平面深的深度用于犬皮肤肥大细胞瘤（MCT）的切除。已经发表了几项评估手术边缘小于传统建议的研究。这项系统评价的目的是确定外侧手术切缘<3 cm的切除MCT是否导致不完全切除和局部肿瘤复发的发生率低。数字书目数据库的系统搜索是由两名作者（AR和LES）进行的，筛选摘要以识别相关的科学文章。对皮肤MCT对狗进行手术治疗的研究进行了综述。进行数据提取，并进行个别研究的质量和利用手术切缘的证据强度< 评估了3 cm切除MCT的能力。结果从通过数据库搜索确定的最初78篇引文中，经过两次相关性筛选后，保留了4篇文章进行数据抽象。有两项研究是回顾性观察性研究，一项是前瞻性病例系列研究，另一项是前瞻性临床试验。使用GRADE系统识别的证据质量水平评估较低。在2 cm和3 cm处切除MCT与不完全切除和复发的发生率相对较低有关。结论尽管整体证据质量低下，但仍可以建议切除Patnaik I级和II级犬皮肤MCT（<4 cm），侧缘2 cm和筋膜深1处，导致不完整率低切除和局部肿瘤复发。