BACKGROUND Cola nitida is commonly chewed in many West African cultures to ease hunger pangs and sometimes for their stimulant and euphoriant qualities. Metoclopramide is a known substrate for P-gp, SULT2A1 and CYP2D6 and studies have revealed that caffeine- a major component of Cola nitida can induce P-glycoprotein (P-gp), SULT2A1 and SULT1A1, hence a possible drug interaction may occur on co-administration. The aim of this study was to investigate the pharmacokinetic interactions of Cola nitida and metoclopramide in rabbits. METHODS The study was performed in two stages using five healthy male rabbits with a 1-week washout period between treatments. Stage one involved oral administration of metoclopramide (0.5 mg/kg) alone while in the second stage, metoclopramide (0.5 mg/kg) was administered concurrently with Cola nitida (0.7 mg/kg). Blood samples were collected after each stage at predetermined intervals and analyzed for plasma metoclopramide concentration using HPLC. RESULTS Compared with control, the metoclopramide/Cola nitida co-administration produced a decrease in plasma concentration of metoclopramide at all the time intervals except at the 7th hour. The following pharmacokinetic parameters were also decreased: area under the curve (51%), peak plasma concentration (39%), half-life (51%); while an increase in elimination rate constant (113%) and clearance rate (98%) were noted indicating rapid elimination of the drug. A minimal decrease in absorption rate (10%) was also observed. CONCLUSIONS The results of this study reveal a possible herb-drug interaction between Cola nitida and metoclopramide.

中文翻译：

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口服可乐尼迪达对甲氧氯普胺在家兔体内药代动力学的影响。

背景技术可乐nitida通常在许多西非文化中被咀嚼，以缓解饥饿感，有时还因为它们具有刺激性和欣快性。甲氧氯普胺是P-gp，SULT2A1和CYP2D6的已知底物，研究表明咖啡因是可乐尼迪达的主要成分，可以诱导P-糖蛋白（P-gp），SULT2A1和SULT1A1，因此可能在Co上发生药物相互作用-行政。这项研究的目的是调查可乐尼达和甲氧氯普胺在兔体内的药代动力学相互作用。方法使用五个健康的雄性兔子分两个阶段进行研究，两次治疗之间的清洗期为1周。第一阶段包括单独口服甲氧氯普胺（0.5 mg / kg），而在第二阶段，甲氧氯普胺（0.5 mg / kg）与可乐尼达（0.7 mg / kg）同时给药。在每个阶段之后以预定间隔收集血样，并使用HPLC分析血浆中甲氧氯普胺的浓度。结果与对照组相比，除第7小时外，在所有时间间隔内，甲氧氯普胺/可乐尼的共同给药均使甲氧氯普胺的血浆浓度降低。以下药代动力学参数也降低了：曲线下面积（51％），血浆峰值浓度（39％），半衰期（51％）；同时观察到消除率常数（113％）和清除率（98％）的增加表明药物的快速消除。还观察到吸收率的最小降低（10％）。结论这项研究的结果表明可乐尼达和甲氧氯普胺之间可能存在药草相互作用。