BACKGROUND Developing objective and repeatable indicators to evaluate the efficacy of PVRL treatment is important. The quantification of vitreous cells is a traditional criterion; however slight changes are difficult to ascertain. Spectral domain optical coherence tomography (SD-OCT) is objective, repeatable, and easily explained. The purpose of this study is to provide a longitudinal observation of OCT in PVRL treated with intravitreal injections of methotrexate (MTX) and to evaluate the utility of OCT in monitoring responsiveness of PVRL to treatment. METHODS The medical records of patients with biopsy-positive PVRL attending our hospital between January 2016 and September 2017 who received intravitreal injections of MTX were included in this study. Pre- and post-treatment OCT images were reviewed independently by two researchers. RESULTS Of the 24 cases reviewed, 10 patients (18 eyes) were included. SD-OCT abnormalities at the initial visit included vitreous cells (18/18), OR (outer retina) fuzzy borders (12/18), PED (pigment epithelium detachments) (9/18), subretinal hyperreflective infiltration (3/18), intraretinal infiltration (8/18), and SRF (subretinal fluid) (4/18). Post induction treatment, SRF in cases with RD (retinal detachment) was absorbed, and subretinal fibrosis appeared. Other lesions were significantly reduced. Post consolidation treatment, OR fuzzy borders, PED and SRF disappeared in 2 eyes, intraretinal infiltration disappeared in 1 eye, and other abnormalities further improved. Additionally, retinal fibrosis was observed in 3 eyes. One month post maintenance treatment, all abnormalities observed at the first visit vanished. At the last visit, OCT showed subretinal fibrosis and in 3 eyes (16.7%), the disruption of outer retina in 9 eyes (50%) and thinning of the whole layer in 4 eyes (22.2%). CONCLUSIONS Our observations reveal that characteristic OCT features in PVRL patients can reduce gradually and finally vanish with therapy. We propose that SD-OCT may be employed to monitor the responsiveness of PVRL to treatment, which may influence decision making in the management of this disease.

中文翻译：

---

OCT成像的纵向观察是监测玻璃体腔注射甲氨蝶呤治疗的原发性玻璃体视网膜淋巴瘤的重要工具。

背景技术开发客观和可重复的指标以评估PVRL治疗的有效性是重要的。玻璃体细胞的定量是一个传统的标准。但是，很难确定微小的变化。光谱域光学相干断层扫描（SD-OCT）客观，可重复且易于解释。这项研究的目的是提供玻璃体腔内注射甲氨蝶呤（MTX）治疗的PVRL中OCT的纵向观察，并评估OCT在监测PVRL对治疗的反应性方面的实用性。方法本研究包括2016年1月至2017年9月在我院就诊的活检阳性PVRL患者接受玻璃体内注射MTX的病历。两名研究人员分别对治疗前后的OCT图像进行了独立审查。结果在回顾的24例病例中，包括10例（18眼）。初次就诊时SD-OCT异常包括玻璃体细胞（18/18），OR（视网膜外）模糊边界（12/18），PED（色素上皮脱离）（9/18），视网膜下高反射性浸润（3/18） ，视网膜内浸润（8/18）和SRF（视网膜下液）（4/18）。诱导治疗后，RD（视网膜脱离）患者的SRF被吸收，并出现视网膜下纤维化。其他病变明显减少。巩固治疗后，OR边界模糊，PED和SRF消失2眼，视网膜内浸润消失1眼，其他异常进一步改善。另外，在3只眼中观察到视网膜纤维化。维持治疗后一个月，第一次就诊时观察到的所有异常都消失了。在最后一次访问时，OCT显示视网膜下纤维化，其中3眼（16.7％），9眼（50％）的视网膜外层破裂和4眼（22.2％）的整个层变薄。结论我们的观察结果表明，PVRL患者的OCT特征可以逐渐减少，最终消失。我们建议SD-OCT可用于监测PVRL对治疗的反应性，这可能会影响该疾病管理的决策制定。