BACKGROUND Impaired physical function due to muscle weakness and exercise intolerance reduces the ability to perform activities of daily living in patients with end-stage kidney disease, and by consequence, Health-Related Quality of Life (HRQoL). Furthermore, the risk of falls is an aggregate of physical function and, therefore, could be associated with HRQoL as well. The present study examined the associations between objective and subjective measures of physical function, risk of falls and HRQoL in haemodialysis patients. METHODS This cross-sectional multicentre study included patients on maintenance haemodialysis. Physical function (quadriceps force, handgrip force, Sit-to-Stand, and six-minute walking test), the risk of falls (Tinetti, FICSIT-4, and dialysis fall index) and HRQoL (PROMIS-29 and EQ-5D-3 L) were measured and analysed descriptively, by general linear models and logistic regression. RESULTS Of the 113 haemodialysis patients (mean age 67.5 ± 16.1, 57.5% male) enrolled, a majority had impaired quadriceps force (86.7%) and six-minute walking test (92%), and an increased risk of falls (73.5%). Whereas muscle strength and exercise capacity were associated with global HRQoL (R2 = 0.32) and the risk of falls, the risk of falls itself was related to psycho-social domains (R2 = 0.11) such as depression and social participation, rather than to the physical domains of HRQoL. Objective measures of physical function were not associated with subjective fatigue, nor with subjective appreciation of health status. CONCLUSIONS More than muscle strength, lack of coordination and balance as witnessed by the risk of falls contribute to social isolation and HRQoL of haemodialysis patients. Mental fatigue was less common than expected, whereas, subjective and objective physical function were decreased.

中文翻译：

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血液透析患者的身体功能，跌倒风险和生活质量之间的关系：一项横断面研究。

背景技术由于肌肉无力和运动不耐受而导致的身体功能受损降低了患有终末期肾脏疾病的患者进行日常生活活动的能力，从而降低了健康相关的生活质量（HRQoL）。此外，跌倒的风险是身体机能的总和，因此也可能与HRQoL有关。本研究检查了血液透析患者的身体功能的客观和主观衡量指标，跌倒风险和HRQoL之间的关联。方法这项横断面多中心研究包括接受维持性血液透析的患者。身体机能（股四头肌力，握力，坐姿和六分钟步行测试），跌倒风险（Tinetti，FICSIT-4，透析线性下降指数）和HRQoL（PROMIS-29和EQ-5D-3 L）进行描述和描述，采用一般线性模型和logistic回归分析。结果纳入的113名血液透析患者（平均年龄67.5±16.1，男性57.5％）中，多数股四头肌力量受损（86.7％）和六分钟步行测试（92％），跌倒的风险增加（73.5％）。 。肌肉力量和运动能力与整体HRQoL（R2 = 0.32）和跌倒的风险相关，而跌倒的风险本身则与心理社会领域（R2 = 0.11）有关，例如抑郁和社交参与，而不是与HRQoL的物理域。客观的身体机能测量与主观疲劳无关，也与主观健康状况无关。结论不仅仅是肌肉力量，跌倒的风险证明缺乏协调和平衡会导致血液透析患者的社交孤立和HRQoL。精神疲劳的发生率低于预期，而主观和客观身体机能下降。