BACKGROUND Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail. METHODS We investigated the association between NWCO and hyperuricemia among Japanese adults aged 40-64 years who had undergone periodic health examinations between April 2013 and March 2014. Obesity was defined as a body mass index (BMI) ≥25 kg/m2 and central obesity was determined as a waist-to-height ratio (WHtR) ≥0.5. We classified the participants into the following groups based according to having obesity and central obesity: normal weight (BMI 18.5-24.9 kg/m2) without (NW; WHtR < 0.5) and with (NWCO) central obesity, and obesity without (OB) and with (OBCO) central obesity. Hyperuricemia was defined as serum uric acid > 7.0 and ≥ 6.0 mg/dL in men and women, respectively, or under medical treatment for hyperuricemia. Alcohol intake was classified as yes (daily and occasional consumption) and none (no alcohol consumption). Odds ratios (OR) and 95% confidence intervals (CI) for hyperuricemia were calculated using a logistic regression model. RESULTS We analyzed data derived from 96,863 participants (69,241 men and 27,622 women). The prevalences of hyperuricemia in men and women were respectively, 21.4 and 11.0%, and of participants with NWCO respectively 15.6 and 30.0%. The adjusted OR for hyperuricemia was significantly increased in OBCO compared with NW, regardless of sex (men: OR, 2.12; 95%CI; 2.03-2.21; women: OR, 3.54; 95%CI, 3.21-3.90) and were statistically significant in NWCO compared with NW (men: OR, 1.44; 95%CI, 1.36-1.52; women: OR, 1.41; 95%CI, 1.27-1.57). The results were similar regardless of alcohol consumption. CONCLUSIONS We found that NWCO and OBCO were associated with hyperuricemia in middle-aged Japanese men and women. Middle-aged Japanese adults with normal weight but having central obesity should be screened using a combination of BMI and WHtR and educated about how to prevent hyperuricemia.

中文翻译：

---

在日本，正常体重与中型肥胖和高尿酸血症之间的关联性的横断面研究。

背景技术一些研究表明，正常体重的中型肥胖（NWCO）与心血管疾病的危险因素如高血压，血脂异常和糖尿病有关。但是，尚未详细研究NWCO与高尿酸血症之间的关系。方法我们调查了2013年4月至2014年3月间接受定期健康检查的40-64岁日本成年人中NWCO与高尿酸血症之间的关系。肥胖定义为体重指数（BMI）≥25 kg / m2，中枢肥胖为确定为腰高比（WHtR）≥0.5。根据肥胖和中枢性肥胖，我们将参与者分为以下几类：体重正常（BMI 18.5-24.9 kg / m2），无（NW； WHtR <0.5），有（NWCO）中性肥胖，没有（OB）和有（OBCO）中心型肥胖的肥胖症。高尿酸血症被定义为分别为男性或女性或接受过高尿酸血症治疗的血清尿酸> 7.0和≥6.0 mg / dL。酒精摄入量分为“是”（每天和偶尔摄入）和“没有”（没有酒精消耗）。使用logistic回归模型计算高尿酸血症的赔率（OR）和95％置信区间（CI）。结果我们分析了来自96,863名参与者（69,241名男性和27,622名女性）的数据。男性和女性高尿酸血症的患病率分别为21.4％和11.0％，而NWCO的参与者分别为15.6和30.0％。与NW相比，无论男女，OBCO的高尿酸血症校正OR均显着增加（男性：OR，2.12； 95％CI； 2.03-2.21；女性：OR，3.54； 95％CI，3.21-3。90），并且在NWCO中与NW相比具有统计学意义（男性：OR，1.44； 95％CI，1.36-1.52；女性：OR，1.41； 95％CI，1.27-1.57）。无论饮酒如何，结果都是相似的。结论我们发现NWCO和OBCO与日本中年男性和女性的高尿酸血症有关。体重正常但患有中型肥胖的日本中年成年人应使用BMI和WHtR进行筛查，并接受有关如何预防高尿酸血症的教育。