Sensory neurons and immune cells share a common microenvironmental niche for surveying tissue integrity. The immune and nervous systems both sense deviations in homeostasis and initiate protective responses and, upon malfunction, also jointly contribute to disease. Barrier tissues are heavily innervated by nociceptors, the sensory neurons that detect noxious stimuli, leading to pain and itch. The same tissues are also home to diverse immune cells that respond to infections and injury. The physical proximity of nociceptors and immune cells allows for direct local interactions between the two, independent of the CNS. We discuss in this study their ligand–receptor–based interactions and propose the need to shift from studying individual neuroimmune interactions to exploring the reciprocal neuroimmune interaction network in its entirety: the “neuroimmune interactome.” Identification of the nature of the interactome in health and its plasticity in disease will unravel the functional consequences of interactions between nociceptors and immune cells.

中文翻译：

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解开塑料外周神经免疫相互作用组

感觉神经元和免疫细胞共享一个共同的微环境生态位，用于调查组织完整性。免疫系统和神经系统都可以感知体内平衡的偏差并启动保护性反应，并且在出现故障时也会共同导致疾病。屏障组织受到伤害感受器的严重支配，伤害感受器是检测有害刺激的感觉神经元，导致疼痛和瘙痒。相同的组织也是对感染和损伤作出反应的多种免疫细胞的家园。伤害感受器和免疫细胞的物理接近允许两者之间的直接局部相互作用，独立于中枢神经系统。我们在这项研究中讨论了它们基于配体-受体的相互作用，并提出需要从研究个体神经免疫相互作用转向全面探索相互神经免疫相互作用网络：“神经免疫相互作用组”。识别健康中相互作用组的性质及其在疾病中的可塑性将揭示伤害感受器和免疫细胞之间相互作用的功能后果。