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Harnessing the active site triad: merging hemilability, proton responsivity, and ligand-based redox-activity.
Dalton Transactions ( IF 3.5 ) Pub Date : 2020-01-07 , DOI: 10.1039/c9dt04470a
Douglas F Baumgardner 1 , Wyatt E Parks 1 , John D Gilbertson 1
Affiliation  

Metalloenzymes catalyze many important reactions by managing the proton and electron flux at the enzyme active site. The motifs utilized to facilitate these transformations include hemilabile, redox-active, and so called proton responsive sites. Given the importance of incorporating and understanding these motifs in the area of coordination chemistry and catalysis, we highlight recent milestones in the field. Work incorporating the triad of hemilability, redox-activity, and proton responsivity into single ligand scaffolds will be described.

中文翻译:

利用活性位点三元组:合并半稳定性、质子响应性和基于配体的氧化还原活性。

金属酶通过管理酶活性位点的质子和电子通量来催化许多重要的反应。用于促进这些转化的基序包括半不稳定的、氧化还原活性的和所谓的质子响应位点。鉴于在配位化学和催化领域整合和理解这些主题的重要性,我们重点介绍了该领域最近的里程碑。将描述将半稳定性、氧化还原活性和质子响应性三元组结合到单个配体支架中的工作。
更新日期:2020-01-07
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