Nonionic Water-Soluble and Cytocompatible Poly(amide acrylate)s,Macromolecules

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Nonionic Water-Soluble and Cytocompatible Poly(amide acrylate)s
Macromolecules ( IF 5.1 ) Pub Date : 2020-01-06 , DOI: 10.1021/acs.macromol.9b02267
Ayaat M. Mahmoud ₁ , Joshua P. Morrow ₁ , David Pizzi ₁ , Sepa Nanayakkara ₂ , Thomas P. Davis ₁ , Kei Saito ₂ , Kristian Kempe _{1,

3}

Affiliation

We report secondary amide side-chain-bearing polyacrylates with tunable aqueous solubility and cellular interaction. Redox-initiated reversible addition-fragmentation chain transfer polymerization of methylamide ethyl acrylate (MAmEA) and ethylamide ethyl acrylate (EAmEA) yielded well-defined homopolymers. P(MAmEA) and P(EAmEA) possess high glass-transition temperatures compared to the equivalent alkylated polyacrylates. P(EAmEA) showed a degree of polymerization and concentration-dependent lower critical solution temperature (LCST) behavior, which can be fine-tuned over a biologically relevant range through copolymerization of both monomers. No cytotoxicity against NIH 3T3 and RAW 264.7 cell lines was observed. Detailed cellular interaction studies revealed cell associations for P(MAmEA) similar to poly(N-acryloylmorpholine), a well-known nonionic water-soluble polymer and colocalization of both homopolymers with lysosomes. Due to the simple access of these monomers, the aqueous solubility, cytocompatibility, and cellular interaction of the homopolymers, and the possibility to combine them with a large number of acrylates, they hold great promise to become suitable building blocks for biomedical materials.

中文翻译：

非离子水溶性和细胞相容性聚丙烯酰胺丙烯酸酯

我们报告具有可调节的水溶性和细胞相互作用的仲酰胺侧链聚丙烯酸酯。氧化甲基引发的丙烯酸甲酰胺乙酯（MAmEA）和乙酰胺丙烯酸乙酯（EAmEA）的可逆加成-断裂链转移聚合反应产生了定义明确的均聚物。与等效的烷基化聚丙烯酸酯相比，P（MAmEA）和P（EAmEA）具有较高的玻璃化转变温度。P（EAmEA）表现出一定程度的聚合度和与浓度有关的下临界溶液温度（LCST）行为，可以通过两种单体的共聚在生物学相关的范围内进行微调。没有观察到针对NIH 3T3和RAW 264.7细胞系的细胞毒性。详细的细胞相互作用研究表明P（MAmEA）的细胞联想与poly（N-丙烯酰吗啉），一种众所周知的非离子水溶性聚合物，两种均聚物与溶酶体的共定位。由于这些单体的简单获取，均聚物的水溶性，细胞相容性和细胞相互作用，以及将它们与大量丙烯酸酯结合的可能性，它们具有很大的希望成为适合生物医学材料的基础。

更新日期：2020-01-07

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