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Probing Cancer Metastasis at a Single-Cell Level with a Raman-Functionalized Anionic Probe.
Nano Letters ( IF 9.6 ) Pub Date : 2020-01-09 , DOI: 10.1021/acs.nanolett.9b04288 Priya Dharmalingam 1 , Krishnan Venkatakrishnan 2 , Bo Tan 2
Nano Letters ( IF 9.6 ) Pub Date : 2020-01-09 , DOI: 10.1021/acs.nanolett.9b04288 Priya Dharmalingam 1 , Krishnan Venkatakrishnan 2 , Bo Tan 2
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Cancer metastasis is the primary reason for cancer-related deaths, yet there is no technique capable of detecting it due to cancer pathogenesis. Current cancer diagnosis methods evaluate tumor samples as a whole/pooled sample process loses heterogeneous information in the metastasis state. Hence, it is not suitable for metastatic cancer detection. In order to gain complete information on metastasis, it is desirable to develop a nondestructive detection method that can evaluate metastatic cells with sensitivity down to single-cell resolution. Here we demonstrated self-functionalized anionic quantum probes for in vitro metastatic cancer detection at a single-cell concentration. We achieved this by incorporating a nondestructive SERS ability within the generated probes by integrating anionic surface species and NIR plasmon resonance. To the best of our knowledge, this was the first time that metastatic cancer cells were detected through their neoplastic transformations. With reliable diagnostic information at the single-cell sensitivity in an in vitro state, we successfully discriminated against cancer malignancy states.
中文翻译：
用拉曼功能化阴离子探针在单细胞水平上探测癌症转移。
癌症转移是癌症相关死亡的主要原因，但由于癌症的发病机理，尚无技术能够检测到。当前的癌症诊断方法评估肿瘤样本，因为整个/合并样本过程在转移状态下会丢失异质信息。因此，它不适用于转移性癌症的检测。为了获得有关转移的完整信息，期望开发一种无损检测方法，该方法可以以低至单细胞分辨率的灵敏度评估转移细胞。在这里，我们展示了自功能化的阴离子量子探针，用于在单细胞浓度下进行体外转移性癌症检测。我们通过整合阴离子表面物质和NIR等离子体激元共振，在生成的探针中整合了无损SERS能力，从而实现了这一目标。据我们所知，这是第一次通过肿瘤转化检测到转移性癌细胞。凭借在体外状态下单细胞敏感性的可靠诊断信息，我们成功区分了癌症恶性状态。
更新日期：2020-01-09
中文翻译：
用拉曼功能化阴离子探针在单细胞水平上探测癌症转移。
癌症转移是癌症相关死亡的主要原因，但由于癌症的发病机理，尚无技术能够检测到。当前的癌症诊断方法评估肿瘤样本，因为整个/合并样本过程在转移状态下会丢失异质信息。因此，它不适用于转移性癌症的检测。为了获得有关转移的完整信息，期望开发一种无损检测方法，该方法可以以低至单细胞分辨率的灵敏度评估转移细胞。在这里，我们展示了自功能化的阴离子量子探针，用于在单细胞浓度下进行体外转移性癌症检测。我们通过整合阴离子表面物质和NIR等离子体激元共振，在生成的探针中整合了无损SERS能力，从而实现了这一目标。据我们所知，这是第一次通过肿瘤转化检测到转移性癌细胞。凭借在体外状态下单细胞敏感性的可靠诊断信息，我们成功区分了癌症恶性状态。
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