Autofluorescence imaging for recurrence detection in skin cancer postoperative scars.,Journal of Biophotonics

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Autofluorescence imaging for recurrence detection in skin cancer postoperative scars.
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-01-13 , DOI: 10.1002/jbio.201900162
Mindaugas Tamošiūnas ₁ , Emilija V Plorina ₁ , Marta Lange ₁ , Aleksandrs Derjabo ₂ , Ilona Kuzmina ₁ , Dmitrijs Bļizņuks ₃ , Janis Spigulis ₁

Affiliation

This clinical study is a first attempt to use autofluorescence for recurrence diagnosis of skin cancer in postoperative scars. The proposed diagnostic parameter is based on a reduction in scar autofluorescence, evaluated in the green spectral channel. The validity of the method has been tested on 110 postoperative scars from 56 patients suspected of non‐melanoma skin cancer, with eight patients (13 scars) available for the repeated examination. The recurrence diagnosis within a scar has been made after two subsequent autofluorescence check‐ups, representing the temporal difference between the scar autofluorescence amplitudes as a vector. The recognition of recurrence has been discussed to represent the significant deviations from the value of vector angle θ. This new autofluorescence‐based method can be easily integrated into the postoperative monitoring of surgical scars and can help diagnose the recurrence of skin cancer from the early stage of scar development.

中文翻译：

自体荧光成像用于皮肤癌术后瘢痕复发检测。

这项临床研究是首次尝试将自体荧光用于术后疤痕皮肤癌的复发诊断。所提出的诊断参数基于在绿色光谱通道中评估的疤痕自发荧光的减少。该方法的有效性已在56名疑似非黑色素瘤皮肤癌患者的110例术后瘢痕中进行了测试，其中8例患者（13处瘢痕）可供重复检查。疤痕内的复发性诊断是在随后的两次自发荧光检查之后做出的，代表了疤痕自发荧光幅度之间的时间差异作为矢量。讨论了递归识别以表示与向量角θ值的显着偏差。这种基于自体荧光的新方法可以轻松地整合到手术疤痕的术后监测中，并且可以帮助从疤痕发展的早期诊断皮肤癌的复发。

更新日期：2020-01-13

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