Is the Hitman in Cardiac Death Hidden in the Sympathetic Nervous System Remodeling?,Journal of the American College of Cardiology

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Is the Hitman in Cardiac Death Hidden in the Sympathetic Nervous System Remodeling?
Journal of the American College of Cardiology ( IF 21.7 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.jacc.2019.11.018
Gennaro Pagano ₁ , Alessandro Cannavo ₂ , Giuseppe Rengo ₃

Affiliation

SEE PAGE 1 P remature ventricular contractions (PVCs) are too-early heartbeats originating in the ventricle, disrupting the heart’s normal rhythm. PVCs are very common in the general population being present in up to 75% of subjects monitored with 24-h electrocardiogram Holter (1,2). PVCs are considered benign and are usually asymptomatic in subjects without heart disease (1); however, they increase the risk of cardiomyopathy, heart failure, and sudden cardiac death in patients with structural heart disease (3). For this reason, PVCs are of great interest to both researchers and clinicians, because they represent an important risk factor requiring a better knowledge on the pathogenic mechanisms and the identification of novel treatments. Indeed, the precise mechanisms and the pathogenesis of PVC-induced cardiac dysfunction remain largely unknown. A dysfunction in the autonomic nervous system (ANS) has been associated with PVCs (4). ANS regulates key aspects of cardiovascular function, including contraction, heart rate, and blood pressure, but also several additional functions in cardiomyocytes (4). The heart is richly innervated by the autonomic terminals, with ganglion cells located either outside or inside of the heart (4,5). ANS is subdivided into the sympathetic nervous system (SNS) and

中文翻译：

交感神经系统重塑中隐藏着心死杀手？

参见第 1 页心室过早收缩 (PVC) 是起源于心室的过早心跳，扰乱了心脏的正常节律。PVC 在普通人群中非常常见，在 24 小时心电图动态心电图监测的受试者中，多达 75% 的受试者存在 (1,2)。PVC 被认为是良性的，在没有心脏病的受试者中通常没有症状 (1)；然而，它们会增加结构性心脏病患者发生心肌病、心力衰竭和心源性猝死的风险 (3)。出于这个原因，PVCs 对研究人员和临床医生都很感兴趣，因为它们代表了一个重要的风险因素，需要更好地了解致病机制和确定新的治疗方法。事实上，PVC 引起的心脏功能障碍的确切机制和发病机制在很大程度上仍然未知。自主神经系统 (ANS) 的功能障碍与 PVC 相关 (4)。ANS 调节心血管功能的关键方面，包括收缩、心率和血压，但也调节心肌细胞的其他一些功能 (4)。心脏受到自主神经末梢的丰富支配，神经节细胞位于心脏的外部或内部 (4,5)。ANS 分为交感神经系统 (SNS) 和

更新日期：2020-01-01

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