Influence of Semifluorinated Alkane Surface Domains on Phase Behavior and Linear and Nonlinear Viscoelasticity of Phospholipid Monolayers.,Langmuir

当前位置： X-MOL 学术 › Langmuir › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Influence of Semifluorinated Alkane Surface Domains on Phase Behavior and Linear and Nonlinear Viscoelasticity of Phospholipid Monolayers.
Langmuir ( IF 3.7 ) Pub Date : 2020-01-16 , DOI: 10.1021/acs.langmuir.9b03521
Salomé Mielke ₁ , Xianhe Liu ₂ , Marie Pierre Krafft ₂ , Motomu Tanaka _{1,

3}

Affiliation

Semifluorinated alkanes self-assemble into 30-40 nm-large surface domains (hemimicelles) at the air/water interface. They have been drawing increasing attention to stabilize microbubbles coated with lipids, which are used for enhancing the contrast in sonographic imaging. Although previous studies suggested that semifluorinated alkanes increase the stability of phospholipid membranes, little is known about how semifluorinated alkanes influence phase behaviors and mechanical properties of lipid-coated microbubbles. As a well-defined model of microbubble surfaces, we prepared monolayers consisting of a mixture of phospholipids and semifluorinated alkanes at the air/water interface and investigated the influence of hemimicelles of semifluorinated alkanes on the phase behavior and interfacial viscoelastic properties of phospholipid monolayers. Hemimicelles are phase-separated from phospholipids and accumulate at the phase boundary, which strongly modulates the correlation between solid phospholipid domains. Intringuingly, we found that the mixed monolayer of semifluorinated alkanes and phospholipids possesses linear and nonlinear viscoelastic properties comparable to those of phospholipid monolayers. Since the mixing of semifluorinated alkanes and phospholipids enables one to overcome the intrinsically low stability of pure semifluorinated alkanes against the change in the surface area of microbubbles through the partial dissolution of gas into the aqueous phase, this is a promising strategy for the stable coating of microbubbles in ultrasound diagnosis.

中文翻译：

半氟化烷烃表面域对磷脂单分子层的相行为以及线性和非线性粘弹性的影响。

半氟化烷烃在空气/水界面处自组装成30-40 nm-大的表面区域（半纤维素）。他们已经越来越多地关注稳定用脂质包裹的微泡，这些微泡用于增强超声成像的对比度。尽管先前的研究表明，半氟化烷烃可提高磷脂膜的稳定性，但对半氟化烷烃如何影响脂质包覆的微泡的相行为和机械性能的了解甚少。作为定义明确的微泡表面模型，我们制备了在空气/水界面处由磷脂和半氟化烷烃混合物组成的单分子层，并研究了半氟化烷烃的半胶束对磷脂单分子层的相行为和界面粘弹性的影响。半胶束与磷脂相分离，并在相界处聚集，这强烈调节了固体磷脂结构域之间的相关性。有趣地，我们发现，半氟化烷烃和磷脂的混合单层具有与磷脂单层相当的线性和非线性粘弹性质。由于半氟化烷烃和磷脂的混合使人们能够克服纯半氟化烷烃固有的低稳定性，以防止由于气体部分溶解到水相中而使微泡表面积发生变化，因此这对于稳定地包被三氟甲烷是一种很有希望的策略超声诊断中的微气泡。它强烈调节固体磷脂结构域之间的相关性。有趣地，我们发现，半氟化烷烃和磷脂的混合单层具有与磷脂单层相当的线性和非线性粘弹性质。由于半氟化烷烃和磷脂的混合使人们能够克服纯半氟化烷烃固有的低稳定性，以防止由于气体部分溶解到水相中而使微泡表面积发生变化，因此这对于稳定地包被三氟甲烷是一种很有希望的策略超声诊断中的微气泡。它强烈调节固体磷脂结构域之间的相关性。有趣地，我们发现，半氟化烷烃和磷脂的混合单层具有与磷脂单层相当的线性和非线性粘弹性质。由于半氟化烷烃和磷脂的混合使人们能够克服纯半氟化烷烃固有的低稳定性，以防止由于气体部分溶解到水相中而使微泡表面积发生变化，因此，这对于稳定地包被三聚氰胺是一种很有前途的策略超声诊断中的微气泡。

更新日期：2020-01-16

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11