Development of an SBU‐Based Mechanochemical Approach for Drug‐Loaded MOFs,European Journal of Inorganic Chemistry

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Development of an SBU‐Based Mechanochemical Approach for Drug‐Loaded MOFs
European Journal of Inorganic Chemistry ( IF 2.2 ) Pub Date : 2020-01-31 , DOI: 10.1002/ejic.201901194
Jan Nawrocki ₁ , Daniel Prochowicz ₁ , Andrzej Wiśniewski ₂ , Iwona Justyniak ₁ , Piotr Goś ₃ , Janusz Lewiński _{1,

2}

Affiliation

Metal–organic frameworks (MOFs) have attracted a great deal of attention in the areas of biomedicine due to their versatile porous structures and are potentially ideal vehicles for loading bioactive molecules and controlling the release of small molecules. Current approaches for encapsulation of drug molecules in MOFs are usually based on multistep wet processes. We report here a novel simple and rapid solid‐state process that combines the mechanosynthesis of HKUST‐1 and the encapsulation of ibuprofen (IBU‐H), as a model drug molecule, in a one‐pot reaction involving a pre‐assembled [Cu₂(IBU)₄]·2DMF cluster. The ibuprofen‐loaded MOF composite (with 58.5 wt.‐% loading capacity) was also studied as a drug delivery carrier system in phosphate buffered saline (PBS) solution at 37 °C.

中文翻译：

基于SBU的MOF的机械化学方法的开发

金属有机骨架（MOF）由于其通用的多孔结构而在生物医学领域引起了广泛的关注，并且是装载生物活性分子和控制小分子释放的潜在理想载体。在MOF中封装药物分子的当前方法通常基于多步湿法工艺。我们在这里报告了一种新颖，简单，快速的固态过程，该过程将HKUST-1的机械合成与布洛芬（IBU-H）的包封（作为模型药物分子）结合在一起，涉及一个预先组装的[Cu ₂（IBU）₄ ] ·2DMF集群。还在37°C的磷酸盐缓冲盐水（PBS）溶液中研究了布洛芬负载的MOF复合材料（具有58.5 wt。％的负载能力）作为药物输送载体系统。

更新日期：2020-01-31

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