Transition‐Metal‐Free Radical C−H Methylation of Quinoxalinones with TBHP,Asian Journal of Organic Chemistry

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Transition‐Metal‐Free Radical C−H Methylation of Quinoxalinones with TBHP
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-01-17 , DOI: 10.1002/ajoc.201900758
Xiaona Rong ₁ , Liujun Jin ₂ , Yugui Gu ₁ , Guang Liang ₂ , Qinqin Xia ₂

Affiliation

A highly efficient and generally applicable iodine‐mediated C−H methylation of quinoxalinones by using TBHP as the methylating reagent was developed. The methodology has the advantages of a metal‐free strategy, easy to handle reagents and functional group tolerance. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.

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