Tripodal Squaramide Derivative as a Neutral Chloride Ionophore for Whole Blood and Sweat Chloride Measurement,Electroanalysis

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Tripodal Squaramide Derivative as a Neutral Chloride Ionophore for Whole Blood and Sweat Chloride Measurement
Electroanalysis ( IF 2.7 ) Pub Date : 2020-01-07 , DOI: 10.1002/elan.201900693
Lingling Fan ₁ , Tingting Xu ₁ , Junjun Feng ₁ , Zihan Ji ₁ , Le Li ₁ , Xinhao Shi ₁ , Chunxiu Tian ₁ , Yu Qin ₁

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A tripodal squaramide derivative was synthesized and characterized as a new neural ionophore for chloride ion. Squaramide based compounds are known to be better hydrogen bonding receptors than urea derivatives because they donate four hydrogen bonds to anions, while the tripodal structure provides a 3D geometry optimum for spherical anion complexation. The ionophore demonstrated high selectivity over salicylate and heparin that are major interferences for chloride measurement in biological samples with direct potentiometric method. The new ionophore based solid‐contact electrodes were fabricated and showed the measuring range of 10⁻⁵ to 1 M chloride ion in the presence of 1 mM of salicylate and heparin with near Nernstian slope of 55 mV/decade. The sensor was successfully applied for the chloride measurement in undiluted heparinized whole blood and artificial sweat samples with our clinical analyzer.

中文翻译：

三脚架方酰胺衍生物作为中性氯化物离子载体用于全血和汗液氯化物的测量

合成了三脚架方酰胺衍生物，并将其表征为氯离子的新型神经离子载体。已知基于方酰胺的化合物比脲衍生物具有更好的氢键受体，因为它们为阴离子提供四个氢键，而三脚架结构则提供了最适合球形阴离子络合的3D几何形状。离子载体对水杨酸盐和肝素具有很高的选择性，这是直接电位法对生物样品中氯离子测量的主要干扰。制备了新的基于离子载体的固体接触电极，其测量范围为10 ^-5在1 mM水杨酸盐和肝素的存在下，在Nernstian斜率附近为55 mV /十年时，可将其转化为1 M氯离子。该传感器已使用我们的临床分析仪成功地用于未稀释的肝素化全血和人造汗液样品中的氯化物测量。

更新日期：2020-01-07

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