MUSIe001-A cell line was derived from a Southeast Asian (SEA) type deletion α⁰-thalassemia embryo. The SEA deletion embryo was donated for research with informed consent. This cell line shows normal hESC morphology, expresses all pluripotent markers, and has the potential to differentiate into all three germ layers in vitro and in vivo. The MUSIe001-A line has normal karyotype and is free from mycoplasma contamination. PCR analysis confirmed the MUSIe001-A cell line to be a SEA type deletion. MUSIe001-A is a valuable proof of principle model for gene therapy that will facilitate the development of new treatments for affected foetuses.

MUSIe001-A细胞系源自东南亚（SEA）型缺失^α0地中海贫血胚胎。在知情同意下，将SEA缺失胚胎捐赠给研究。该细胞系显示正常的hESC形态，表达所有多能性标志物，并具有在体外和体内分化为所有三个细菌层的潜力。MUSIe001-A品系具有正常的核型，没有支原体污染。PCR分析证实MUSIe001-A细胞系是SEA类型缺失。MUSIe001-A是基因治疗原理模型的宝贵证明，这将有助于为受影响的胎儿开发新的治疗方法。