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Production of Zn(l-Met)2 Chelate with Improved Flowability by Reactive Crystallization
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2020-01-13 , DOI: 10.1021/acs.cgd.9b01298 Wang-Soo Kim 1 , Ung-Hwi Yoon 1 , Kee-Kahb Koo 1
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2020-01-13 , DOI: 10.1021/acs.cgd.9b01298 Wang-Soo Kim 1 , Ung-Hwi Yoon 1 , Kee-Kahb Koo 1
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The production of zinc l-methionine chelate (Zn(l-Met)2) by a fed-batch reactive crystallization process was reported with enhanced flowability. Zn(l-Met)2 chelate was obtained through the injection of an aqueous zinc salt into a high pH solution of aqueous l-Met. The total volume of aqueous zinc salt required to induce Zn(l-Met)2 precipitation, as a function of injection rate and operating temperature, was determined by the real-time attenuated total reflection Fourier transform infrared spectroscopic analysis of a mixed suspension. The smaller this volume at the metastable limit, the larger chelate particles with a high flowability were found to be obtained. Furthermore, improved Zn(l-Met)2 recovery was achieved upon careful selection of cation and anion species, which are not involved with Zn(l-Met)2 precipitation in two reagent solutions, based on the salting effects. Finally, Zn(l-Met)2 particles with excellent flowability and recovery of higher than 97% were successfully produced with a controlled injection of aqueous zinc salts at 30 °C.
中文翻译：
通过反应结晶生产具有改善的流动性的Zn（l-Met）2螯合物
据报道，通过补料分批反应结晶法生产1-蛋氨酸锌螯合物（Zn（1- Met）2）具有提高的流动性。Zn（1- Met）2螯合物是通过将锌盐水溶液注入到1- Met水溶液的高pH溶液中而获得的。诱导Zn（l -Met）2所需的锌盐水溶液的总体积通过实时衰减的全反射傅里叶变换红外光谱分析混合悬浮液，可以确定随注入速率和工作温度而变化的沉淀。在亚稳态极限处的该体积越小，发现获得的具有较高流动性的螯合物颗粒越大。此外，基于盐分作用，通过精心选择不参与两种试剂溶液中Zn（1- Met）2沉淀的阳离子和阴离子种类，可以提高Zn（1- Met）2的回收率。最后，Zn（l -Met）2 通过在30°C下控制注射锌盐水溶液，成功生产出具有出色流动性和高于97％的回收率的颗粒。
更新日期：2020-01-13
中文翻译：
通过反应结晶生产具有改善的流动性的Zn（l-Met）2螯合物
据报道，通过补料分批反应结晶法生产1-蛋氨酸锌螯合物（Zn（1- Met）2）具有提高的流动性。Zn（1- Met）2螯合物是通过将锌盐水溶液注入到1- Met水溶液的高pH溶液中而获得的。诱导Zn（l -Met）2所需的锌盐水溶液的总体积通过实时衰减的全反射傅里叶变换红外光谱分析混合悬浮液，可以确定随注入速率和工作温度而变化的沉淀。在亚稳态极限处的该体积越小，发现获得的具有较高流动性的螯合物颗粒越大。此外，基于盐分作用，通过精心选择不参与两种试剂溶液中Zn（1- Met）2沉淀的阳离子和阴离子种类，可以提高Zn（1- Met）2的回收率。最后，Zn（l -Met）2 通过在30°C下控制注射锌盐水溶液，成功生产出具有出色流动性和高于97％的回收率的颗粒。
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