BACKGROUND Engaging diverse populations in biomedical research, including biospecimen donation, remains a national challenge. This study examined factors associated with an invitation to participate in biomedical research, intent to participate in biomedical research in the future, and participation in biomedical research and biospecimen donation among a diverse, multilingual, community-based sample across 3 distinct geographic areas. METHODS Three National Cancer Institute-designated cancer centers engaged in community partnerships to develop and implement population health assessments, reaching a convenience sample of 4343 participants spanning their respective catchment areas. Data harmonization, multiple imputation, and multivariable logistic modeling were used. RESULTS African Americans, Hispanic/Latinos, and other racial minority groups were more likely to be offered opportunities to participate in biomedical research compared to whites. Access to care, history of cancer, educational level, survey language, nativity, and rural residence also influenced opportunity, intent, and actual participation in biomedical research. CONCLUSIONS Traditionally underserved racial and ethnic groups reported heightened opportunity and interest in participating in biomedical research. Well-established community partnerships and long-standing community engagement around biomedical research led to a diverse sample being reached at each site and may in part explain the current study findings. However, this study illustrates an ongoing need to establish trust and diversify biomedical research participation through innovative and tailored approaches. National Cancer Institute-designated cancer centers have the potential to increase opportunities for diverse participation in biomedical research through community partnerships and engagement. Additional work remains to identify and address system-level and individual-level barriers to participation in both clinical trials and biospecimen donation for research.

中文翻译：

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与生物医学研究参与3个国家癌症研究所指定的癌症中心的社区样本相关的因素。

背景技术使包括生物样本捐赠在内的不同人群参与生物医学研究仍然是一项全国性挑战。这项研究检查了与邀请参加生物医学研究，将来打算参加生物医学研究以及参与生物医学研究和生物标本捐赠有关的因素，这些样本来自3个不同地理区域的多样化，多语言，基于社区的样本中。方法三个由美国国家癌症研究所指定的癌症中心与社区建立了伙伴关系，以制定和实施人口健康评估，从而为遍布各自流域的4343名参与者提供了便利样本。使用了数据协调，多重插补和多变量逻辑模型。结果非裔美国人，西班牙裔/拉丁裔，与白人相比，其他种族少数群体更有可能获得参与生物医学研究的机会。获得医疗服务，癌症病史，教育水平，调查语言，出生日期和农村居民的身份也影响了生物医学研究的机会，意图和实际参与。结论传统上服务不足的种族和族裔群体报告了参与生物医学研究的机会和兴趣增加了。围绕生物医学研究的完善的社区合作伙伴关系和长期的社区参与导致在每个站点获得了各种各样的样本，并可能部分解释了当前的研究结果。但是，这项研究表明，不断需要通过创新和量身定制的方法来建立信任并使生物医学研究参与多元化。美国国家癌症研究所指定的癌症中心有可能通过社区合作伙伴关系和参与来增加参与生物医学研究的机会。尚需进行其他工作，以识别和解决参与临床试验和生物标本捐赠的系统级和个人级障碍。