The study investigated chitosan coated nanostructured lipid carriers (NLCs) for oral delivery of albendazole in treatment of trichinellosis. NLCs comprised precirol and oleic acid with Tween and Span 80. Dicetylphosphate was used as charging agent to allow chitosan coating. Trichinella spiralis infected mice were used and albendazole suspension, coated or uncoated NLCs were orally administered at different stages of infection. NLCs were spherical with size of 188 and 200 nm for coated and uncoated NLC, respectively. Treatment during intestinal phase reduced worm count with NLCs showing better rank. This was reflected further by reduced larvae count and improved histopathological features. Starting treatment in the migrating phase reduced larval count by 62.9, 99.6 and 89.5 % after administration of suspension, coated and uncoated NLCs, respectively. The same rank was recorded for the encysted phase. NLCs enhanced the efficacy of albendazole against Trichinella spiralis compared with suspension with chitosan coated NLCs being superior.

中文翻译：

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壳聚糖包被的纳米结构脂质载体可增强阿苯达唑对旋毛虫的体内功效。

该研究调查了壳聚糖包衣的纳米结构脂质载体（NLC）用于口服阿苯达唑治疗旋毛虫病的方法。NLCs包含precirol和油酸以及Tween和Span80。磷酸二十六烷基酯用作填充剂，可进行壳聚糖包衣。使用旋毛虫感染的小鼠，并在感染的不同阶段口服施用阿苯达唑悬浮液，包被的或未包被的NLC。NLC是球形的，分别用于涂覆和未涂覆的NLC，尺寸分别为188和200 nm。肠道阶段的治疗减少了蠕虫数量，而NLC显示出更好的等级。幼虫数量减少和组织病理学特征改善进一步反映了这一点。给予悬浮液，包衣和未包衣的NLC后，在迁移期开始处理可使幼虫数量减少62.9％，99.6％和89.5％，分别。进入阶段记录了相同的等级。与悬浮液相比，NLCs增强了阿苯达唑对旋毛虫的功效，其中壳聚糖包被的NLCs具有更好的效果。