BACKGROUND Non-adherence to tuberculosis (TB) treatment jeopardizes the individual's health and contributes to disease transmission and drug resistance. New patient-centered strategies are needed to improve TB treatment outcomes. PURPOSE To convert and expand a texting-based intervention into a mobile optimized application (app), evaluate the feasibility of an added self-administered paper-based drug metabolite test, and identify needs and preferences to inform their iterative design. METHODS Qualitative methods using focus groups and field testing with patients in active TB treatment were used to gather initial input on the converted intervention design, content and issues using at home test strips to report medication adherence. Seven participants were recruited from an outpatient clinic within a regional public reference hospital specialized in respiratory diseases in Argentina. Thematic analyses were conducted on the transcripts and session notes. RESULTS Participants considered interactive communication, access to answers to frequently asked questions, and tracking of progress in treatment as important. Participants reported having many questions and uncertainties at initiation of treatment and emphasized a need for reliable information, assurance and support from both providers and peers. Other suggestions included streamlining the graphical user interface for easier and shorter data entry times and usability. CONCLUSIONS Overall feedback from the participants regarding the intervention was positive, reporting that it was useful and relevant, and they were eager to contribute their ideas for improvement and additional functionality. Valuable feedback to improve functionality and meet the needs of end-users were obtained to inform the generation of new design ideas for refinement and testing in a pilot study.

中文翻译：

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转换和扩展移动支持干预措施：进行主动结核治疗的个人进行的焦点小组和现场测试发现。

背景技术对结核病（TB）治疗的不依从危害个人的健康并有助于疾病传播和耐药性。需要新的以患者为中心的策略来改善结核病治疗结果。目的要将基于文本的干预措施转换并扩展到移动优化应用程序（app）中，评估添加的自管理纸质药物代谢物测试的可行性，并确定需要和偏好以告知其迭代设计。方法采用定性方法，采用焦点小组和对活动性TB治疗患者进行现场测试，以收集关于转换后的干预设计，内容和问题的初始信息，并使用家庭试纸报告药物依从性。七名参与者是从阿根廷一家专门从事呼吸系统疾病的地区性公共参考医院的门诊诊所招募的。对成绩单和会议记录进行了主题分析。结果参与者认为互动交流，获得常见问题的答案以及跟踪治疗进展非常重要。参加者报告说，开始治疗时存在许多问题和不确定性，并强调需要提供者和同行提供可靠的信息，保证和支持。其他建议包括简化图形用户界面，以简化和缩短数据输入时间并提高可用性。结论参与者对干预的总体反馈是积极的，报告说这种干预是有用的和相关的，他们渴望为改进和附加功能贡献自己的想法。获得了宝贵的反馈意见，以改善功能并满足最终用户的需求，从而为在初步研究中完善和测试新设计思路提供了依据。