The incorporation of poly(DL-lactic-co-glycolic acid) (PLGA) particles into calcium phosphate cements (CPCs) is an effective strategy to enhance CPC macroporosity and degradation. However, bone regeneration is hindered until hydrolytic PLGA degradation starts a few weeks after implantation. Additionally, CPC and CPC/PLGA injectability and cohesion are suboptimal. In the current study, poly(N-vinylpyrrolidone) (PVP), a water-soluble polymer, was incorporated as a porogen in CPC and CPC/PLGA composites to enhance handling properties and early-stage macroporosity formation. Further, the effect of PVP molecular weight (Mw) and particle size was studied. The results showed that PVP incorporation increased both injectability and cohesion of the CPC pastes, especially with addition of high Mw PVP. Moreover, the in vitro degradation studies revealed that incorporation of PVP induced an initial mass loss during the first week of incubation. In combination with PLGA, small PVP particles induced a higher mass loss at an early stage than large PVP particles, but this effect was no longer apparent after 4 weeks of incubation. In contrast, the incorporation of low Mw PVP had a stronger effect on in vitro degradation in the long term compared to high Mw. Finally, the presence of PLGA porogens appeared to be necessary for adequate CPC degradation.

将聚（DL-乳酸-乙醇酸共聚物）（PLGA）颗粒掺入磷酸钙水泥（CPC）中是提高CPC大孔率和降解的有效策略。但是，直到植入后几周水解PLGA降解开始，才阻碍骨再生。此外，CPC和CPC / PLGA的可注射性和内聚性都不理想。在当前的研究中，聚（N-乙烯基吡咯烷酮）（PVP）是一种水溶性聚合物，已被掺入CPC和CPC / PLGA复合材料中作为致孔剂，以增强处理性能和早期大孔形成。此外，研究了PVP分子量（Mw）和粒径的影响。结果表明，PVP掺入增加了CPC糊料的可注射性和内聚力，特别是添加了高Mw PVP。而且，体外降解研究表明，在培养的第一周内掺入PVP会引起初始质量损失。与PLGA组合使用时，小的PVP颗粒在早期阶段会比大的PVP颗粒引起更高的质量损失，但是在孵育4周后这种效果不再明显。相反，与高Mw相比，低Mw PVP的掺入对长期体外降解具有更强的影响。最后，PLGA致孔剂的存在似乎是适当的CPC降解所必需的。