Glioblastoma multiforme (GBM) is an extremely aggressive malignant brain tumor. Despite advances in treatment modalities, it remains largely incurable. This unfavorable prognosis for GBM is at least partly due to the lack of a successful drug delivery system across the blood-brain barrier (BBB). The delivery of drugs through nanomedicines combined with less invasive alternative therapies represents an important hope for the future of these incurable brain tumors. Whey protein nanocarriers represent promising strategy for targeted drug delivery to tumor cells by enhancing the drug's bioavailability and distribution, and reducing the body's response towards drug resistance. They have been extensively studied to find new alternatives for capacity to encapsulate different drugs and no need for cross-linkers. In this study, we report for the first time the incorporation and administration of Aluminum phthalocyanine chloride (AlClPc)-loaded whey protein drug delivery system (AlClPc-PDDS) for the treatment of glioblastoma brain cancer. This system was designed and optimized (with the use of the spray drying technique) to obtain the required particle size (in the range of 100 to 300 nm), zeta potential and drug loading. Our results suggest that we have developed a drug delivery system from a low-cost raw material and preparation method that is capable of incorporating hydrophobic drugs which, in combination with irradiation, cause photodamage to neoplasic cells, working as an effective adjuvant treatment for malignant glioma.

多形胶质母细胞瘤（GBM）是一种极具侵略性的恶性脑肿瘤。尽管治疗方式有所进步，但仍基本无法治愈。GBM的这种不良预后至少部分是由于缺乏跨血脑屏障（BBB）的成功的药物输送系统。通过纳米药物与侵入性较小的替代疗法相结合的药物递送代表了这些不可治愈的脑肿瘤的未来的重要希望。乳清蛋白纳米载体通过增强药物的生物利用度和分布并减少人体对药物耐药性的反应，代表了靶向药物向肿瘤细胞递送的有前途的策略。他们已经进行了广泛的研究，以找到新的替代方法来封装不同的药物并且不需要交联剂。在这个研究中，我们首次报告了铝氯化酞菁（AlClPc）负载的乳清蛋白药物递送系统（AlClPc-PDDS）的合并和给药，用于治疗胶质母细胞瘤脑癌。设计和优化该系统（使用喷雾干燥技术）以获得所需的粒径（100至300 nm），ζ电位和载药量。我们的结果表明，我们已经从低成本的原料和制备方法开发出了一种药物输送系统，该系统能够掺入疏水性药物，该药物与放射线结合可对赘生性细胞产生光损伤，可作为恶性神经胶质瘤的有效辅助治疗。